Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Description

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Conditions

Cardiac Arrest, Inflammation, Obesity

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Study Overview

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Study Details

Study overview

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Immunoinflammatory and Metabolic Responses in Post Cardiac Arrest Syndrome (PCAS)

Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Condition
Cardiac Arrest
Intervention / Treatment

-

Contacts and Locations

Portland

Maine Medical Center, Portland, Maine, United States, 04102

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 18 years or older
  • * Admitted to the intensive care unit after cardiac arrest episode
  • * Unresponsive after resuscitation
  • * Moribund / actively dying at the time of evaluation
  • * Informed consent cannot be obtained within 24 hours of resuscitation
  • * Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

MaineHealth,

Sergey Ryzhov, MD, PhD, PRINCIPAL_INVESTIGATOR, MaineHealth Institute for Research

David B Seder, MD, PRINCIPAL_INVESTIGATOR, MaineHealth

Study Record Dates

2026-03-20