High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Eligibility Criteria

• * The subject has a surgical indication for pancreatectomy (pancreaticoduodenectomy, distal pancreatectomy, total pancreatectomy) as determined by the treating physician/surgeon
• * A diagnosis of pancreatic or other periampullary cancer is suspected preoperatively
• * In the opinion of the surgeon, the subject has no medical contraindications to pancreatectomy
• * Age ≥18 years of age.
• * The subject is willing to consent to randomization of EAL-S vs. standard EAL-W vs. no extensive lavage. (SOC)
• * The subject does not have a surgical indication for pancreatectomy
• * In the opinion of the surgeon, the subject has medical contraindications to pancreatectomy
• * Age \< 18 years of age
• * The subject is not willing to consent to EAL-S vs. EAL-W vs. no extensive lavage (SOC)
• * Known benign or indolent disease, including benign pancreatic cystic tumors or pancreatic endocrine tumors) without possible risk of malignancy
• * Other malignancy within five years, unless the probability of recurrence of the prior malignancy is \< 5% as determined by the principal investigator based on available information. Patient's curatively treated for squamous and basal cell carcinoma of the skin or patients with a history of malignant tumor in the past that have been disease free for at least five years are also eligible for this study.
• * Evidence of metastatic disease preoperatively.