RECRUITING

Investigations of Dementia in Parkinson Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Official Title

Investigations of Dementia in Parkinson Disease

Quick Facts

Study Start:2016-06
Study Completion:2030-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02763683

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.
  1. * history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.
  2. * severe systemic diseases.
  3. * inability to lie still for 90 minutes.
  4. * metallic implants, pacemakers, or any other contraindication to MRI.
  5. * refusal to consent to brain donation.

Contacts and Locations

Study Contact

Kaleigh Oberndorfer, RN, BSN
CONTACT
314 3620420
kaleigh@wustl.edu
Susan Donovan
CONTACT
314 362 6026
donovan@wustl.edu

Principal Investigator

Joel S Perlmutter, MD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine

Study Locations (Sites)

Washington University in St. Louis
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Joel S Perlmutter, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-06
Study Completion Date2030-03

Study Record Updates

Study Start Date2016-06
Study Completion Date2030-03

Terms related to this study

Keywords Provided by Researchers

  • Parkinsons Disease
  • PET Imaging
  • PIB
  • VAT
  • Dementia

Additional Relevant MeSH Terms

  • Parkinsons