RECRUITING

Pancreas Registry and High Risk Registry

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the pancreas, and patients at high-risk of pancreatic cancer such as those with a family history of pancreatic cancer or with a family history of a syndrome known to be associated with pancreatic cancer. Pancreatic cancer is the fourth leading cause of death from cancer in the United States. However, little is known about the development of pancreatic cancer and pancreatic diseases in individuals with the above conditions. Knowledge of how family history, environmental exposures, and inflammatory lesion of the pancreas contribute to the development of pancreatic cancer and pancreatic diseases is essential. You may qualify to take part in this research study because you have inflammation in the pancreas, a pancreatic cyst, pre-cancerous lesions of the pancreas, pancreatic cancer, a family history of pancreatic cancer, or a family history of a syndrome known to be associated with pancreatic cancer. We will also be collecting a blood sample from all participants for DNA isolation. Sometimes we are born with genes or DNA that give us an increased or decreased chance of developing an illness later in life. Genetic material will be isolated from your blood for further study. You may also choose to provide additional blood samples for serum and plasma extraction. Serum and plasma are components of the blood which can be used to measure indicators of disease in the blood, called biomarkers,for pancreatic diseases. Clinical data and biological specimens contained in this study may be used for a wide variety of future related studies to the cause, diagnosis, outcome and treatment of pancreatic cancer. Funds for conducting this research are provided by Mount Sinai.

Official Title

Pancreas Disease and High Risk Registry

Quick Facts

Study Start:2013-03-01
Study Completion:2033-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02775461

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least 1 first degree relative affected with Pancreatic Cancer
  2. * Any of (BRCA1, BRCA2, PALB2, ATM) mutations + 1 family member with Pancreatic Cancer
  3. * mFAMMM (p16,CDKN2A mutations) + 1 family member with Pancreatic cancer
  4. * Known mutation carrier for STK11 (Peutz Jeghers Syndrome)
  5. * Lynch syndrome (HNPCC) + 1 family PDAC
  6. * Known mutation carrier for Hereditary pancreatitis
  7. * Individuals with a history of pancreatic cyst(s) (IPMN's) that measure ≥ 1 cm
  1. * Patients who do not speak English or Spanish
  2. * Refusal by patient
  3. * Individuals under the age of 18 years

Contacts and Locations

Study Contact

Arielle Labiner
CONTACT
212-241-2244
Arielle.labiner@mssm.edu
Aimee Lucas, MD, MS
CONTACT
212-241-0101
aimee.lucas@mssm.edu

Principal Investigator

Aimee Lucas, MD, MS
PRINCIPAL_INVESTIGATOR
Icahn School of Medicine at Mount Sinai

Study Locations (Sites)

Icahn School of Medicine at Mount Sinai
New York, New York, 10029
United States

Collaborators and Investigators

Sponsor: Icahn School of Medicine at Mount Sinai

  • Aimee Lucas, MD, MS, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2013-03-01
Study Completion Date2033-11

Study Record Updates

Study Start Date2013-03-01
Study Completion Date2033-11

Terms related to this study

Keywords Provided by Researchers

  • Pancreas Cancer
  • Chronic Pancreatitis
  • Pancreatic Cyst
  • BRCA1
  • BRCA2
  • Lynch Syndrome
  • Peutz-Jeghers syndrome
  • ATM mutation
  • FAMMM Syndrome
  • Pancreatitis
  • Family History of Pancreas Cancer
  • Family History of Cancer

Additional Relevant MeSH Terms

  • Pancreas Cancer
  • Pancreatitis
  • Chronic Pancreatitis
  • Pancreatic Cyst
  • Family History of Pancreas Cancer
  • Genetic Mutations