Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Description

This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions. PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi). SECONDARY OBJECTIVE: To collect minimal information on patients treated with adjuvant or systemic therapies according to National Comprehensive Cancer Network (NCCN) guidelines.

Conditions

Melanoma

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Study Overview

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Study Details

Study overview

This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions. PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi). SECONDARY OBJECTIVE: To collect minimal information on patients treated with adjuvant or systemic therapies according to National Comprehensive Cancer Network (NCCN) guidelines.

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Condition
Melanoma
Intervention / Treatment

-

Contacts and Locations

Memphis

St. Jude Children's Research Hospital, Memphis, Tennessee, United States, 38105

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including:
  • * Conventional or "adult-type" melanoma
  • * Spitzoid melanoma/atypical Spitz tumor
  • * Congenital melanoma
  • * Melanoma arising in a giant congenital nevus
  • * Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas)
  • * Participant was \<19 years of age at the time of diagnosis.
  • * Tissue is available for biologic studies.
  • * Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials.
  • * Ocular melanoma
  • * Inability or unwillingness of research participant or legal guardian to consent.
  • * Histologic diagnosis other than melanocytic lesion described in 3.1.1.

Ages Eligible for Study

to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

St. Jude Children's Research Hospital,

Alberto Pappo, MD, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital

Study Record Dates

2041-05-31