ACTIVE_NOT_RECRUITING

A Gene Hunting Study for Familial Papillary Thyroid Cancer

Conditions

Thyroid Papillary Carcinoma Gene Hunting Familial

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.

Official Title

A Strategy to Search for Genes Predisposing to Papillary Carcinoma of the Thyroid When Mutated

Quick Facts

Study Start:1998-08-05

Study Completion:2026-12

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT02776969

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives * Affected and unaffected family members of the proband\* * For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples.	* Known germline predisposition (ex: pathogenic PTEN variant) * Non-English speaking

Inclusion Criteria

Exclusion Criteria

* Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives
* Affected and unaffected family members of the proband\*
* For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples.

* Known germline predisposition (ex: pathogenic PTEN variant)
* Non-English speaking

Contacts and Locations

Principal Investigator

Matthew Ringel, MD

PRINCIPAL_INVESTIGATOR

Ohio State University Comprehensive Cancer Center

Study Locations (Sites)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

United States

Collaborators and Investigators

Sponsor: Ohio State University Comprehensive Cancer Center

Matthew Ringel, MD, PRINCIPAL_INVESTIGATOR, Ohio State University Comprehensive Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date1998-08-05

Study Completion Date2026-12

Study Record Updates

Study Start Date1998-08-05

Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

Papillary Carcinoma
Gene Hunting
Familial

Additional Relevant MeSH Terms

Thyroid