Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

Description

This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.

Conditions

Tumor Surgery

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Study Overview

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Study Details

Study overview

This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.

Effects Of Caloric Restriction On Post-Operative Complications In Sarcoma Patients Treated With Pre-Operative Radiation Therapy

Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

Condition
Tumor Surgery
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts general Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \>18 years
  • * Biopsy proven soft tissue sarcoma located in the lower extremities
  • * Patient to be treated with radiation therapy for a primary lower extremity soft tissue sarcoma or recurrent tumor after surgery, followed by surgical resection
  • * Karnofsky Score ≥ 60%
  • * Body Mass Index (BMI) ≥ 20 kg/m2
  • * Protein levels within normal limits within 45 days of enrollment
  • * Normal kidney and liver function within 45 days of enrollment
  • * Normal blood counts within 45 days of enrollment
  • * Normal chemistries within 45 days of enrollment
  • * Current pregnancy and breast feeding
  • * Other cancers diagnosed within the last 5 years (in situ and/or invasive)
  • * Diabetes mellitus
  • * Current metformin therapy
  • * Other conditions may exclude participants from the study (e.g. intractable nausea/emesis, allergic reaction to shake, patient decides not to have surgery, any medical condition that prevents patient from having surgery)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Santiago A Lozano-Calderón, MD, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2027-05