The Effects of Bariatric Surgeries on Glucose Metabolism

Description

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Conditions

Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass

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Study Overview

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Study Details

Study overview

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

The Effects of Bariatric Surgeries on Glucose Metabolism

The Effects of Bariatric Surgeries on Glucose Metabolism

Condition
Post Bariatric Surgery
Intervention / Treatment

-

Contacts and Locations

San Antonio

Texas Diabetes Institute - University Health System, San Antonio, Texas, United States, 78207

San Antonio

South Texas Veterans Health Care System, San Antonio, Texas, United States, 78229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
  • * Asymptomatic individuals with bariatric surgery
  • * Healthy non-surgical patients with no personal history of diabetes
  • * Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center
  • * Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
  • * RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
  • * Healthy non-surgical patients with personal history of diabetes
  • * History of glaucoma
  • * Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia
  • * Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
  • * Myasthenia gravis
  • * Brain pathology
  • * Enlarged prostate in men

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The University of Texas Health Science Center at San Antonio,

Marzieh Salehi, MD, MS, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center at San Antonio

Study Record Dates

2026-08