RECRUITING

Genetic Markers of Cardiovascular Disease in Epilepsy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This study aims to identify known genetic causes of heart rhythm and sudden death related disorders in patients with epilepsy.

Official Title

Genetic Markers of Cardiovascular Diseases and the Potential Role in Sudden Unexpected Death in Epilepsy.

Quick Facts

Study Start:2016-05
Study Completion:2029-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02824822

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults ages 18 - 50 with a diagnosis of epilepsy or seizures, or syncope or drowning or cardiac arrest or sudden death or an abnormal ECG suggestive of an arrhythmia
  2. * Blood-relatives (Aged 18+) of a patient with a history of epilepsy, seizure, cardiac arrest, sudden death, drowning, syncope or arrhythmia
  1. * Those who are unable to provide written consent.
  2. * Prisoners (vulnerable population)
  3. * Seizures secondary to ischemic events
  4. * Traumatic brain injury resulting in seizures
  5. * History of cranial surgery
  6. * History of brain tumor

Contacts and Locations

Study Contact

Somers CPL Lab
CONTACT
CPL@mayo.edu

Principal Investigator

Virend K. Somers, MD PhD
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Virend K. Somers, MD PhD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-05
Study Completion Date2029-12

Study Record Updates

Study Start Date2016-05
Study Completion Date2029-12

Terms related to this study

Keywords Provided by Researchers

  • Sudden Unexpected Death in Epilepsy
  • SUDEP
  • Sudden Cardiac Arrest
  • Sudden Cardiac Death
  • Sleep
  • Ion channel disease
  • Long QT syndrome
  • Brugada
  • Catecholaminergic Polymorphic Ventricular Tachycardia

Additional Relevant MeSH Terms

  • Epilepsy
  • Seizures
  • Syncope
  • Channelopathy
  • Cardiomyopathies