RECRUITING

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

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Conditions

Mild Cognitive Impairment (MCI)Alzheimer's Disease (AD)amyloidplaquesneuroimagingbiomarkerscognition disorderearly detectionpre-dementiadementiaAlzheimer's diseasetau

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD). The overall goal of the study is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research.

Official Title

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Quick Facts

Study Start:2016-10
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02854033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

ADNI Study Central Phone Number
CONTACT
(213) 821-0569
adni-participate@usc.edu

Principal Investigator

Michael W. Weiner, MD
STUDY_DIRECTOR
University of California, San Francisco
Paul Aisen, MD
PRINCIPAL_INVESTIGATOR
USC Alzheimer's Therapeutic Research Institute (ATRI)
Ronald Peterson, MD, PHD
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

University of Alabama, Birmingham
Birmingham, Alabama, 35294
United States
Banner Alzheimer's Institute
Phoenix, Arizona, 85006
United States
Barrow Neurological Institute
Phoenix, Arizona, 85013
United States
Banner Sun Health Research Institute
Sun City, Arizona, 85351
United States
University of California, Irvine
Irvine, California, 92697
United States
University of California, San Diego
La Jolla, California, 920371707
United States
Long Beach VA Neuropsychiatric Research Program
Long Beach, California, 90822
United States
University of Southern California
Los Angeles, California, 900335310
United States
University of California, Los Angeles
Los Angeles, California, 90095
United States
VA Palo Alto HSC / Stanford School of Medicine
Palo Alto, California, 94304
United States
University of California, San Francisco
San Francisco, California, 94158
United States
University of California, Davis
Walnut Creek, California, 945985900
United States
Yale University School of Medicine
New Haven, Connecticut, 65103330
United States
Georgetown University
Washington, District of Columbia, 200072145
United States
Howard University
Washington, District of Columbia, 200600001
United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, 32224
United States
Wien Center for Clinical Research
Miami Beach, Florida, 331402877
United States
University of South Florida - Health Byrd Alzheimer Institute
Tampa, Florida, 336134808
United States
Emory University
Atlanta, Georgia, 30322
United States
Northwestern University
Chicago, Illinois, 606113010
United States
Rush University Medical Center
Chicago, Illinois, 606123806
United States
Indiana University
Indianapolis, Indiana, 46202
United States
University of Iowa
Iowa City, Iowa, 52242
United States
University of Kansas
Fairway, Kansas, 66205
United States
University of Kentucky
Lexington, Kentucky, 405042681
United States
Johns Hopkins University
Baltimore, Maryland, 212242764
United States
Brigham and Women's Hospital
Boston, Massachusetts, 21155804
United States
Boston University School of Medicine
Boston, Massachusetts, 21182307
United States
University of Michigan, Ann Arbor
Ann Arbor, Michigan, 481052967
United States
Mayo Clinic, Rochester
Rochester, Minnesota, 559050001
United States
Washington University, St. Louis
Saint Louis, Missouri, 631082215
United States
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, 891060100
United States
Albany Medical College
Albany, New York, 12208
United States
Dent Neurologic Institute
Buffalo, New York, 142261727
United States
New York University Medical Center
New York, New York, 100166055
United States
Mount Sinai School of Medicine
New York, New York, 100296552
United States
Columbia University
New York, New York, 10032
United States
Nathan Kline Institute for Psychiatric Research
Orangeburg, New York, 109621159
United States
University of Rochester
Rochester, New York, 14620
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States
Case Western Reserve University
Beachwood, Ohio, 441224312
United States
Ohio State University
Columbus, Ohio, 43210
United States
Oregon Health & Science University
Portland, Oregon, 972393011
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States
Rhode Island Hospital
Providence, Rhode Island, 02903
United States
Butler Hospital Memory and Aging Program
Providence, Rhode Island, 02906
United States
Ralph H. Johnson VA Health Care System
Charleston, South Carolina, 29401
United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37212
United States
University of Texas, Southwestern MC at Dallas
Dallas, Texas, 75390
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
Houston Methodist
Houston, Texas, 77030
United States
University of Wisconsin
Madison, Wisconsin, 537920001
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Michael W. Weiner, MD, STUDY_DIRECTOR, University of California, San Francisco
  • Paul Aisen, MD, PRINCIPAL_INVESTIGATOR, USC Alzheimer's Therapeutic Research Institute (ATRI)
  • Ronald Peterson, MD, PHD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-10
Study Completion Date2024-12

Study Record Updates

Study Start Date2016-10
Study Completion Date2024-12

Terms related to this study

Keywords Provided by Researchers

  • amyloid
  • plaques
  • neuroimaging
  • biomarkers
  • cognition disorder
  • early detection
  • pre-dementia
  • dementia
  • Alzheimer's disease
  • tau

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment (MCI)
  • Alzheimer's Disease (AD)