Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

Eligibility Criteria

• * Ischemic or hemorrhagic stroke at least 6 months prior study enrollment ;
• * Moderate upper-extremity hemiparesis (initial score on the Upper Extremity Fugl-Meyer Assessment between 21 and 55 out of 66) ;
• * Ability to extend at least 2 fingers in the affected hand 10 degrees at any joint with pain-free passive range of motion at least 50% in all joints below the elbow.
• * Cognitive impairment resulting to inability to follow instructions (as assessed with the MMSE) and inability to sustain attention for more than 10 minutes;
• * Current participation in upper-extremity therapy program;
• * Treatment with Botox injections in the affected arm in the previous 3 months and no planned Botox injections before the end of the study;
• * Aphasia sufficient to limit comprehension and completion of the treatment protocol;
• * No more than moderate impairments in paretic UE sensation, passive range of motion, and pain that would limit ability to engage in therapy;
• * Increased muscle tone as indicated by score of \>/= 3 on the Modified Ashworth Scale;
• * Previous diagnosis of dementia;
• * Previous diagnosis of neurological diseases other than Stroke;
• * History of seizures disorder and/or a seizure occuring within the last 6 months;
• * Other conditions affecting function of the stroke affected upper limb;
• * Severe pain in the stroke affected upper limb;
• * Terminal diseases with expected survival \<1 year;