Heart Attack Research Program- Imaging Study

Description

The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.

Conditions

Myocardial Infarction

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Study Overview

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Study Details

Study overview

The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.

Heart Attack Research Program- Imaging Study

Heart Attack Research Program- Imaging Study

Condition
Myocardial Infarction
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama-Birmingham, Birmingham, Alabama, United States, 35294

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

San Diego

UC San Diego Medical Center, San Diego, California, United States, 92103

Stanford

Stanford University, Stanford, California, United States, 94305

Gainesville

University of Florida Medical Center, Gainesville, Florida, United States, 32603

Atlanta

Emory University, Atlanta, Georgia, United States, 30322

Baltimore

Johns Hopkins Medical Center, Baltimore, Maryland, United States, 21287

Lebanon

Dartmouth-Hitchcock, Lebanon, New Hampshire, United States, 03766

Mineola

NYU Winthrop, Mineola, New York, United States, 11501

New York

NYU Langone Medical Center, New York, New York, United States, 10016

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms
  • * Objective evidence of MI (either or both of the following):
  • * Elevation of troponin to above the laboratory upper limit of normal
  • * ST segment elevation of ≥1mm on 2 contiguous ECG leads
  • * Willing to provide informed consent and comply with all aspects of the protocol
  • * Age ≥ 21 years
  • * Stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac catheterization
  • * History of known obstructive coronary artery disease at angiography, including history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
  • * Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1 month)
  • * Alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma
  • * Coronary dissection apparent on angiography
  • * Excessive coronary tortuosity which, in the angiographer's opinion, increases the risks of OCT
  • * eGFR\<45 or contraindication to additional contrast needed for OCT in the opinion of the angiographer or treating physician
  • * Contraindication to MRI (including but not limited to ferromagnetic implants)
  • * Pregnancy
  • * Thrombolytic therapy for STEMI (qualifying event)

Ages Eligible for Study

21 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

NYU Langone Health,

Harmony R Reynolds, MD, PRINCIPAL_INVESTIGATOR, NYU Langone Medical Center

Study Record Dates

2026-06-30