RECRUITING

Heart Attack Research Program- Imaging Study

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.

Official Title

Heart Attack Research Program- Imaging Study

Quick Facts

Study Start:2020-07-01

Study Completion:2026-06-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT02905357

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 99 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms * Objective evidence of MI (either or both of the following): * Elevation of troponin to above the laboratory upper limit of normal * ST segment elevation of ≥1mm on 2 contiguous ECG leads * Willing to provide informed consent and comply with all aspects of the protocol * Age ≥ 21 years	* Stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac catheterization * History of known obstructive coronary artery disease at angiography, including history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) * Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1 month) * Alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma * Coronary dissection apparent on angiography * Excessive coronary tortuosity which, in the angiographer's opinion, increases the risks of OCT * eGFR\<45 or contraindication to additional contrast needed for OCT in the opinion of the angiographer or treating physician * Contraindication to MRI (including but not limited to ferromagnetic implants) * Pregnancy * Thrombolytic therapy for STEMI (qualifying event)

Inclusion Criteria

Exclusion Criteria

* Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms
* Objective evidence of MI (either or both of the following):
* Elevation of troponin to above the laboratory upper limit of normal
* ST segment elevation of ≥1mm on 2 contiguous ECG leads
* Willing to provide informed consent and comply with all aspects of the protocol
* Age ≥ 21 years

* Stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac catheterization
* History of known obstructive coronary artery disease at angiography, including history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
* Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1 month)
* Alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma
* Coronary dissection apparent on angiography
* Excessive coronary tortuosity which, in the angiographer's opinion, increases the risks of OCT
* eGFR\<45 or contraindication to additional contrast needed for OCT in the opinion of the angiographer or treating physician
* Contraindication to MRI (including but not limited to ferromagnetic implants)
* Pregnancy
* Thrombolytic therapy for STEMI (qualifying event)

Contacts and Locations

Study Contact

Harmony R Reynolds, MD

CONTACT

646-501-0302

harmony.reynolds@nyumc.org

Principal Investigator

Harmony R Reynolds, MD

PRINCIPAL_INVESTIGATOR

NYU Langone Medical Center

Study Locations (Sites)

University of Alabama-Birmingham

Birmingham, Alabama, 35294

United States

Cedars-Sinai Medical Center

Los Angeles, California, 90048

United States

UC San Diego Medical Center

San Diego, California, 92103

United States

Stanford University

Stanford, California, 94305

United States

University of Florida Medical Center

Gainesville, Florida, 32603

United States

Emory University

Atlanta, Georgia, 30322

United States

Johns Hopkins Medical Center

Baltimore, Maryland, 21287

United States

Dartmouth-Hitchcock

Lebanon, New Hampshire, 03766

United States

NYU Winthrop

Mineola, New York, 11501

United States

NYU Langone Medical Center

New York, New York, 10016

United States

Columbia University Medical Center/NYPH

New York, New York, 10032

United States

Ohio State University Medical Center

Columbus, Ohio, 43210

United States

St. Luke's University Health Network

Bethlehem, Pennsylvania, 18015

United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213

United States

Seton Heart (Ascension) Univeristy of Austin, Texas

Austin, Texas, 78705

United States

Collaborators and Investigators

Sponsor: NYU Langone Health

Harmony R Reynolds, MD, PRINCIPAL_INVESTIGATOR, NYU Langone Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-07-01

Study Completion Date2026-06-30

Study Record Updates

Study Start Date2020-07-01

Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

Myocardial Infarction
Imaging

Additional Relevant MeSH Terms

Myocardial Infarction