Mild TBI Assessment & Rehabilitation

Description

One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions. When completed, these studies will inform us whether training core attentional self-regulatory control functions via personally-relevant activities will be effective in improving daily life for Veterans with mild TBI and comorbid conditions. The study design will provide a test not only of potential benefits for real life functioning, but also determine to what extent these benefits are related to actual changes in cognitive/behavioral performance and brain networks corresponding to these functions. This project will provide a foundation for future studies to investigate the neural mechanisms that support improvements of cognition and behavior in mTBI.

Conditions

Brain Injuries, Traumatic

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Study Overview

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Study Details

Study overview

One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions. When completed, these studies will inform us whether training core attentional self-regulatory control functions via personally-relevant activities will be effective in improving daily life for Veterans with mild TBI and comorbid conditions. The study design will provide a test not only of potential benefits for real life functioning, but also determine to what extent these benefits are related to actual changes in cognitive/behavioral performance and brain networks corresponding to these functions. This project will provide a foundation for future studies to investigate the neural mechanisms that support improvements of cognition and behavior in mTBI.

Multi-Level Assessment and Rehabilitation of Combat Mild TBI

Mild TBI Assessment & Rehabilitation

Condition
Brain Injuries, Traumatic
Intervention / Treatment

-

Contacts and Locations

San Francisco

San Francisco VA Medical Center, San Francisco, CA, San Francisco, California, United States, 94121-1563

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94158

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18+
  • * A history of mild TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument)
  • * Chronic, stable phase of recovery (\>6 months from last post-concussive event)
  • * Report of residual cognitive difficulties (1 moderate or severe cognitive symptom(s) on the Neurobehavioral Symptom Inventory (NSI)) that interfere(s) with daily function
  • * Able and willing to commit to participate in training and assessments
  • * If on psychoactive medications, must be stable on medications (\> 30 days)
  • * Ages 18+
  • * No history of any (mild to severe) TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument)
  • * Able and willing to commit to participate in assessments
  • * If on psychoactive medications, must be stable on medications (\> 30 days)
  • * A history of moderate or severe TBI
  • * Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g., contraindications to MRI)
  • * Ongoing illicit drug or alcohol abuse (AUDIT\>8)
  • * Psychosis
  • * Severe depression, anxiety or PTSD that precludes participation in research activities
  • * Poor English comprehension
  • * Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD
  • * There will be no restriction in regard to gender, race and socioeconomic status
  • * A history of any mild, moderate, or severe TBI
  • * Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g. contraindications to MRI)
  • * Ongoing illicit drug or alcohol abuse (AUDIT\>8)
  • * Psychosis
  • * Severe depression, anxiety or PTSD that precludes participation in research activities
  • * Poor English comprehension
  • * Eligible participants may have other co-morbid stable neuropscyhiatric disorders, including depression and PTSD.
  • * There will be no restriction in regard to gender, race and socioeconomic status

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Pratik Mukherjee, MD PhD, PRINCIPAL_INVESTIGATOR, San Francisco VA Medical Center, San Francisco, CA

Study Record Dates

2025-12-01