Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines

Eligibility Criteria

• 1. Patients with LVEF \</= 40% documented from treatment with anthracyclines for any malignancy at any dose at any time without evidence of other causes of cardiomyopathy.
• 2. Age \>/= 18 and \</= 90 years of age. English and non-English speaking patients are eligible.
• 3. Documented NYHA class I, II and III.
• 4. For patients who have received trastuzumab: Persistent LV dysfunction must be present 90 days after discontinuation of trastuzumab.
• 5. Able to perform 6 minute walk test.
• 6. Been treated with appropriate maximal medical therapy for heart failure.
• 7. Patient or legally authorized representative able to sign informed consent.
• 1. Evidence of Ischemic Heart Disease as determined by study cardiologist.
• 2. Significant Valvular Disease. (AS with AVA \<1.5 and severe AR and MR)
• 3. History of Familial Cardiomyopathy.
• 4. Recent documented myocarditis within 2 months of enrollment.
• 5. History of Infiltrative cardiomyopathy or restrictive cardiomyopathy.
• 6. Presence of left ventricular thrombus as documented by echocardiography or left ventriculogram.
• 7. Liver function tests \> 3 x upper limit of normal.
• 8. NYHA class IV heart failure.
• 9. Inotropic dependence.
• 10. Unstable or life-threatening arrhythmia.
• 11. For patients not on anticoagulants, INR\>1.5
• 12. Mechanical or Bioprosthetic heart valve.
• 13. Cardiogenic shock.
• 14. Breastfeeding and/or pregnant women.
• 15. Autoimmune disorders on current immunosuppressive therapy.
• 16. Active infection not responding to appropriate therapy as determined by Study Chair.
• 17. Trastuzumab treatment within the last 3 months.
• 18. Automatic implantable cardioverter defibrillator (AICD) placement within the last 30 days.
• 19. AICD firing within the last 30 days.