RECRUITING

Pharmacogenomics of Warfarin in Hispanics and Latinos

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Warfarin is a commonly used blood thinner to treat and prevent blood clots. It is important to take the right dose of warfarin because too much can increase the risk of bleeding and too little can increase the risk of blood clots. This is why patients are closely monitored especially when they begin warfarin therapy. When clinicians prescribe warfarin, they have to consider different factors such as patient's age, body size, diet, and other medications that can interact with warfarin. Certain genes have also been found to affect warfarin dose. Individuals have variations in these genes, which can help explain why some patients need higher dose and others require less. These factors have been used to better predict a patient's warfarin dose requirement. However, these predictions were created based on Caucasian populations and they may not be accurate in predicting a safe warfarin dose if a patient is not Caucasian. This study aims to identify new genetic variation that affects warfarin dosing in Hispanic and Latino populations and try to better predict a Hispanic or Latino patient's warfarin dose requirement.

Official Title

Pharmacogenomics of Warfarin in Hispanics and Latinos

Quick Facts

Study Start:2016-09
Study Completion:2026-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02972385

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least 18 years of age
  2. * Ability to give informed consent
  3. * Therapeutic INR for at least 2 consecutive clinic visits
  4. * Self-identifies as Hispanic or Latino
  1. * Less than 18 years old
  2. * Unable to give informed consent
  3. * Severe hepatic impairment

Contacts and Locations

Study Contact

Jason H Karnes, PharmD, PhD
CONTACT
520-626-1447
karnes@pharmacy.arizona.edu
Talin A Robinson Catalan, MS
CONTACT
520-278-6114
talinrobinson@arizona.edu

Study Locations (Sites)

Banner University Medical Center - Tucson
Tucson, Arizona, 85721
United States

Collaborators and Investigators

Sponsor: University of Arizona

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-09
Study Completion Date2026-09

Study Record Updates

Study Start Date2016-09
Study Completion Date2026-09

Terms related to this study

Keywords Provided by Researchers

  • warfarin
  • blood clotting

Additional Relevant MeSH Terms

  • Thrombosis
  • Hemorrhage