COMPLETED

Short Term Genetic Effects of Chemotherapy on Male Germ Cells

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will determine the short-term effects of chemotherapy on sperm DNA.The study involves the collection of semen sample through ejaculation prior to initiation of chemotherapy and up to three time points after initiation of chemotherapy.

Official Title

Short Term Genetic Effects of Chemotherapy on Male Germ Cells

Quick Facts

Study Start:2013-02
Study Completion:2025-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT02975245

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Be scheduled to undergo treatment with chemotherapeutic agents for a medical indication
  2. * Be able to produce semen samples prior to chemotherapy and one week after first round of chemotherapy
  1. * Men who have previously been treated with chemotherapeutic agents.
  2. * Men with significant oligospermia or azospermia.

Contacts and Locations

Principal Investigator

Kyle Orwig, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh/University of Pittsburgh Medical Center

Study Locations (Sites)

Magee-Womens Hospital
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Kyle Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh/University of Pittsburgh Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2013-02
Study Completion Date2025-04

Study Record Updates

Study Start Date2013-02
Study Completion Date2025-04

Terms related to this study

Keywords Provided by Researchers

  • Male infertility
  • Germ cells
  • Chemotherapy
  • Sperm

Additional Relevant MeSH Terms

  • Cancer