Short Term Genetic Effects of Chemotherapy on Male Germ Cells

Description

This study will determine the short-term effects of chemotherapy on sperm DNA.The study involves the collection of semen sample through ejaculation prior to initiation of chemotherapy and up to three time points after initiation of chemotherapy.

Conditions

Cancer

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Study Overview

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Study Details

Study overview

This study will determine the short-term effects of chemotherapy on sperm DNA.The study involves the collection of semen sample through ejaculation prior to initiation of chemotherapy and up to three time points after initiation of chemotherapy.

Short Term Genetic Effects of Chemotherapy on Male Germ Cells

Short Term Genetic Effects of Chemotherapy on Male Germ Cells

Condition
Cancer
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be scheduled to undergo treatment with chemotherapeutic agents for a medical indication
  • * Be able to produce semen samples prior to chemotherapy and one week after first round of chemotherapy
  • * Men who have previously been treated with chemotherapeutic agents.
  • * Men with significant oligospermia or azospermia.

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Kyle Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh/University of Pittsburgh Medical Center

Study Record Dates

2026-02