This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (\> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol.
Diabetic Nephropathies, Diabetic Glomerulosclerosis
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (\> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol.
Transformative Research in Diabetic Nephropathy
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University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States, 72205
University of Southern California, Los Angeles, California, United States, 90033
Stanford University, Palo Alto, California, United States,
Yale University, New Haven, Connecticut, United States, 06510
Northwestern University, Chicago, Illinois, United States, 60611
University of Michigan, Ann Arbor, Michigan, United States, 48109
University of New Mexico, Albuquerque, New Mexico, United States, 87131
Albert Einstein College of Medicine, Bronx, New York, United States, 10461
Mount Sinai Hospital, New York, New York, United States, 10029
Columbia University, New York, New York, United States, 10032
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to 100 Years
ALL
No
University of Pennsylvania,
Katalin Susztak, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania
2025-06