Image-Guided Gynecologic Brachytherapy

Description

This research is being done to evaluate multimodality imaging, including magnetic resonance imaging-guided therapy (MRT), as a possible treatment for gynecologic cancers. The therapy takes place in the Department of Radiation Oncology at the Johns Hopkins SKCCC. The purpose of this study is to investigate the ability of MRI to successfully guide the placement of the brachytherapy applicator necessary to treat participants' gynecologic cancer. The Investigators want to see if the use of MRI will do a better job of assessing the tumor at the time of brachytherapy than the routinely used CT scan. The Investigators also want to determine if the use of MRI will enable doctors to reduce the radiation dose received by the body during the process of treating the tumor.

Conditions

Cervical Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer, Bladder Cancer

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Study Overview

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Study Details

Study overview

This research is being done to evaluate multimodality imaging, including magnetic resonance imaging-guided therapy (MRT), as a possible treatment for gynecologic cancers. The therapy takes place in the Department of Radiation Oncology at the Johns Hopkins SKCCC. The purpose of this study is to investigate the ability of MRI to successfully guide the placement of the brachytherapy applicator necessary to treat participants' gynecologic cancer. The Investigators want to see if the use of MRI will do a better job of assessing the tumor at the time of brachytherapy than the routinely used CT scan. The Investigators also want to determine if the use of MRI will enable doctors to reduce the radiation dose received by the body during the process of treating the tumor.

A Clinical Trial To Evaluate Image-Guided Gynecologic Brachytherapy In The MR Simulator Suite

Image-Guided Gynecologic Brachytherapy

Condition
Cervical Cancer
Intervention / Treatment

-

Contacts and Locations

Baltimore

The SKCCC at Johns Hopkins, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants must have histologically or cytologically confirmed carcinoma. Central pathology review is not required; however, pathology will be reviewed at the SKCCC at Johns Hopkins.
  • * Site/Stage
  • * Any patient eligible for internal implantation without MR guidance will be considered eligible for this protocol. Standard criteria for internal implantation include:
  • * Carcinoma of the cervix: Stage I-IVA or vaginal recurrence
  • * Carcinoma of the uterus: Stage IIIB (vaginal involvement), inoperable, or vaginal recurrence
  • * Carcinoma of the vagina: Stage I-IVA or vaginal recurrence
  • * Carcinoma of the vulva: Stage I-IVA or recurrence
  • * Carcinoma of the urethra based on treating physician's discretion
  • * Patients who have received prior radiation or chemotherapy may be enrolled on this study.
  • * Age \> 18 years. Children do not develop these malignancies and therefore are not considered candidates for this trial.
  • * Life expectancy of greater than 6 months.
  • * ECOG performance status of \<2 or greater, based on treating physician's discretion
  • * MRI of the pelvis or PET-CT within 4 months before registration
  • * Ability to understand and the willingness to sign a written informed consent document.
  • * Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  • * Absolute neutrophil count \< 500 at the time of enrollment
  • * A history of metal in the head or eyes

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins,

Akila Viswanathan, M.D., PRINCIPAL_INVESTIGATOR, Johns Hopkins Department of Radiation Oncology

Study Record Dates

2028-12