The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

Description

The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1. Partial fat pad harvest with Adipose-Derived Stem Cell (ADSC) transplantation with standard arthroscopic treatment consisting of: partial meniscectomy, cartilage stabilization, loose body removal and selective synovectomy. 2. Standard arthroscopic treatment (above) without cell transplant.

Conditions

Knee Osteoarthritis

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Study Overview

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Study Details

Study overview

The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1. Partial fat pad harvest with Adipose-Derived Stem Cell (ADSC) transplantation with standard arthroscopic treatment consisting of: partial meniscectomy, cartilage stabilization, loose body removal and selective synovectomy. 2. Standard arthroscopic treatment (above) without cell transplant.

The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis: A Randomized Controlled Trial

The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

Condition
Knee Osteoarthritis
Intervention / Treatment

-

Contacts and Locations

Santa Monica

Kerlan Jobe Orthopedic Institute, Santa Monica, California, United States, 90404

Stanford

Stanford University, Stanford, California, United States, 94305

Denver

UC Health Steadman Hawkins Clinic - Denver Inverness, Denver, Colorado, United States, 80112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age between 35 and 70 years-old
  • * Patient is scheduled to undergo one or a combination of the following procedures:
  • * Meniscal debridement or partial menisectomy
  • * Meniscal repair that does not necessitate a different postoperative protocol from meniscal debridement or partial menisectomy
  • * Removal of loose bodies
  • * Chondroplasty
  • * Synovectomy
  • * Soft tissue releases for flexion or extension contracture.
  • * Diagnosis of pre-existing mild to moderate osteoarthritis of the medial or lateral femoral condyle (Kellgren-Lawrence Grade 2 or 3)
  • * \< 6 months of knee pain or \< 6 months of a significant exacerbation of existing knee pain
  • * Physical examination findings consistent with the proposed surgical procedure.
  • * Failure of conservative therapy consisting of a minimum of 6 weeks of physical therapy and trial of anti-inflammatory medications, with or without concomitant bracing and/or injections
  • * Age \< 35 or \> 70 years old
  • * Radiographs demonstrating either no, little or severe osteoarthritis (Kellgren-Lawrence Grade 0, 1 or 4)
  • * Previous injury or surgery to the infrapatellar fat pad (assessed by MRI)
  • * Patient scheduled to undergo any concomitant surgical procedures with the exception of:
  • * Meniscal debridement or partial menisectomy
  • * Meniscal repair that does not necessitate a different postoperative protocol from meniscal debridement or partial menisectomy
  • * Removal of loose bodies
  • * Chondroplasty
  • * Synovectomy
  • * Soft tissue releases for flexion or extension contracture
  • * Prior surgery on ipsilateral knee involving cartilage regeneration (microfracture, Autologous Chondrocyte Implantation, etc) or meniscal transplant/implant
  • * Previous arthroscopy within 1 year
  • * Subchondral edema

Ages Eligible for Study

35 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Jason L Dragoo, MD, PRINCIPAL_INVESTIGATOR, University of Colorado - Anschutz Medical Campus

Seth L Sherman, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2025-12