RECRUITING

Inflammation, Diabetes, Ethnicity and Obesity Cohort

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Obesity affects over one third of US adults (\>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of obesity and its consequences is one of the most important problems of our time. In this proposed study, investigators will recruit participants from a wide range of body mass index (BMI), ethnicity and Diabetes risk to collect data and blood, stool and adipose tissue samples in the San Francisco bay area.

Official Title

Development of a Multi-Ethnic, Multimodal Obesity Cohort

Quick Facts

Study Start:2015-02
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03022682

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Participants will be healthy individuals between the ages of 18-75 years. These cutoffs are designed to allow inclusion of postmenopausal women, and younger/more active patients who are increasingly undergoing bariatric surgery.
  2. * Patients with either diabetes type 2 or the metabolic syndrome will be included in the cohort.
  1. * Participants with chronic kidney disease (\> stage 4)
  2. * Autoimmune/inflammatory disease (e.g., Lupus, Ulcerative Colitis, etc.)
  3. * Unstable angina, New York (NY) class III or IV congestive heart failure or myocardial infarction within 3 months of entry
  4. * Clinically significant liver disease (e.g. Cirrhosis or liver failure)
  5. * Weight \> 450 pounds (DXA scan weight limit)
  6. * History of organ transplant
  7. * Treatment with chemotherapy or radiation therapy at the time of enrollment in study.
  8. * Poorly controlled asthma (participants requiring inhaled glucocorticoids and/or oral glucocorticoids)
  9. * Current nasal corticosteroid use (within the past month)
  10. * Excessive alcohol or substance abuse
  11. * Current use of anabolic steroids or testosterone for bodybuilding purposes. Testosterone use is permitted if prescribed for hypogonadism and dose stable for the past 6 months.
  12. * Patients actively enrolled in interventional trials involving investigational agents
  13. * Pregnant or breast-feeding women
  14. * Appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee.
  15. * History of abnormal clotting
  16. * Previous bariatric surgery
  17. * Anticoagulant use

Contacts and Locations

Principal Investigator

Suneil Koliwad, MD,PhD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California San Francisco
San Francisco, California, 94143
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Suneil Koliwad, MD,PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2015-02
Study Completion Date2025-12

Study Record Updates

Study Start Date2015-02
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • ethnicity
  • inflammation
  • obesity
  • diabetes

Additional Relevant MeSH Terms

  • Obesity
  • Diabetes Mellitus
  • Pre Diabetes