RECRUITING

Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases

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Conditions

Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous SystemSolid tumor malignancyRadiographic evidence of spine metastasisSpine radiosurgeryRadiation therapyRadiotherapyQuestionnairesSurveysXRT

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical research study is to learn whether delivering spine radiosurgery in a single large dose is better than delivering spine radiosurgery over 3 smaller doses. Researchers also want to learn about the effects of a single dose on participant's symptoms, pain, and quality-of-life.

Official Title

Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases: a Randomized Phase II Clinical Trial

Quick Facts

Study Start:2017-01-18
Study Completion:2028-05-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03028337

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. All patients must have histologic proof of solid tumor malignancy and radiographic evidence of spine metastasis
  2. 2. Age \>/=18 years
  3. 3. Eastern Cooperative Oncology Group (ECOG) performance status \</=2 (Karnofsky \>/=60%)
  4. 4. Life expectancy of greater than 6 months
  5. 5. All patients must be able to lie supine
  6. 6. All patients must have no more than 3 contiguous vertebral body levels treated at a single site, and no more than 3 discontiguous vertebral body levels treated
  7. 7. All patients must have radiographic evidence of progression at a spinal site previously irradiated greater than 6 months prior to randomization. This includes indirect radiation exposure to spinal site.
  8. 8. All patients must have received prior conventional external-beam radiation therapy (cEBRT) to the site of interest to no more than a critical neural tissue dose equivalent dose (EQD)2/2 of 42 Gy in a single session or 50 Gy cumulative over multiple sessions and cauda equina dose EQD2/2 of 50 Gy in a single session or 60 Gy cumulative over multiple session. EQD2/2 is calculated as follows: EQD2/2= biologically effective dose (BED)/(1+d/alpha beta)) where BED=nd(1+d/(alpha beta)) and n=number of fractions, d=dose per fraction and alpha beta ratio of 2.
  9. 9. All patients must have a vertebral body site to be treated located from T1 to L5
  10. 10. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
  11. 11. All patients must sign informed consent verifying that they are aware of the investigational nature of this study in keeping with the rules and policies of MD Anderson Cancer Center. The only acceptable consent is the one approved by MD Anderson IRB.
  12. 12. Patients undergoing prior surgery or laser interstitial thermotherapy are allowed
  13. 13. Both men and women of all races and ethnic groups are eligible for this trial.
  1. 1. Patients unable to undergo magnetic resonance imaging (MRI) of the spine
  2. 2. Prior radiation at the site of interest within 6 months
  3. 3. Prior history of radiation at the site of interest resulting in a critical neural tissue dose of EQD2/2 of \>42 Gy in a single session
  4. 4. Patients unable to lie flat comfortably for 2 hours
  5. 5. Pregnancy status will be obtained at time of consent as is routine for all radiation patients. Pregnant women are excluded from this study because radiation has the potential for teratogenic or abortifacient effects
  6. 6. Patients with a histology of lymphoma and myeloma histologies

Contacts and Locations

Study Contact

Amol J. Ghia, MD
CONTACT
713-563-2300
CR_Study_Registration@mdanderson.org

Principal Investigator

Amol J. Ghia, MD
PRINCIPAL_INVESTIGATOR
M.D. Anderson Cancer Center

Study Locations (Sites)

University of Texas MD Anderson Cancer Center
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: M.D. Anderson Cancer Center

  • Amol J. Ghia, MD, PRINCIPAL_INVESTIGATOR, M.D. Anderson Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-01-18
Study Completion Date2028-05-30

Study Record Updates

Study Start Date2017-01-18
Study Completion Date2028-05-30

Terms related to this study

Keywords Provided by Researchers

  • Malignant neoplasms of eye brain and other parts of central nervous system
  • Solid tumor malignancy
  • Radiographic evidence of spine metastasis
  • Spine radiosurgery
  • Radiation therapy
  • Radiotherapy
  • Questionnaires
  • Surveys
  • XRT

Additional Relevant MeSH Terms

  • Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System