Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving hematopoietic stem cell transplant (HSCT) conditioning, experience CIV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with psychiatric illness, does not interact with chemotherapy and is inexpensive. We hypothesize that the addition of olanzapine to standard antiemetics will improve chemotherapy-induced vomiting (CIV) control in children receiving highly emetogenic chemotherapy
Vomiting in Infants and/or Children, Nausea, Hematopoietic System--Cancer, Oncology
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving hematopoietic stem cell transplant (HSCT) conditioning, experience CIV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with psychiatric illness, does not interact with chemotherapy and is inexpensive. We hypothesize that the addition of olanzapine to standard antiemetics will improve chemotherapy-induced vomiting (CIV) control in children receiving highly emetogenic chemotherapy
RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
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University of California, San Francisco, California, United States, 94158
The Children's Mercy Hospital, Kansas City, Missouri, United States, 64108
Columbia University/Morgan Stanley Children's Hospital, New York, New York, United States, 10032
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States, 27599-7220
Nationwide Children's Hospital, Columbus, Ohio, United States, 43205
Medical University of South Carolina, Charleston, South Carolina, United States, 29425
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30 Months to 18 Years
ALL
No
The Hospital for Sick Children,
Lee Dupuis, RPh, PhD, PRINCIPAL_INVESTIGATOR, The Hospital for Sick Children
Muhammad Ali, MD, PRINCIPAL_INVESTIGATOR, The Hospital for Sick Children
2025-04