Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

Eligibility Criteria

• 1. Males and females within the ages of 18-85
• 2. Diagnosis of soft tissue sarcoma that has been histologically confirmed by an approved reference pathologist
• 3. Sarcoma of lower extremity location
• 4. Treatment plan that includes neo-adjuvant radiation therapy followed by surgical resection
• 5. Expected primary wound closure performed at the time at surgery
• 6. Any disease stage
• 7. Any tumor grade
• 8. Any histologic subtype
• 9. First or recurrent presentations
• 10. No vascular invasion or resection/repair/reconstruction that results in decreased perfusion of the extremity
• 11. No history of radiation therapy to the tumor and/or surgical area prior to the current treatment being studied
• 12. Must be able to comply with follow up visits
• 13. Must be able to provide own consent
• 1. Patients under the age of 18, or over the age of 85.
• 2. Treatment plan that doesn't include neo-adjuvant radiation and surgical excision
• 3. Sarcoma location other than lower extremity
• 4. History of radiation therapy to the tumor and/or surgical area prior to the current treatment being studied
• 5. High dose steroid therapy (defined as \>5mg prednisone, or equivalent, daily)
• 6. Active treatment with chemotherapy
• 7. Inability of the patient to provide informed consent (i.e. dementia, cognitive impairment, non-English speakers)
• 8. Plan for post operative radiation therapy
• 9. Vascular invasion or resection/repair/reconstruction that results in decreased perfusion of the extremity
• 10. Vascular disease resulting in clinically apparent compromise in blood flow to the treatment extremity (i.e. peripheral vascular disease with diminished pulses, venous insufficiency with clinical evidence of vascular congestion)
• 11. Actively uncontrolled diabetes mellitus (documentation of history of diabetes mellitus with A1c\>8)
• 12. Active deep vein thrombosis in the treatment extremity
• 13. Inability to comply with follow up visits
• 14. Pregnant females (women of childbearing potential must have a negative serum pregnancy test prior to enrollment)