COMPLETED

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.

Official Title

Operant Conditioning of Motor Evoked Responses to Improve Quadriceps Function in Individuals With Anterior Cruciate Ligament Reconstruction

Quick Facts

Study Start:2017-09-21
Study Completion:2025-11-24
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT03209531

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * aged 18-45 years
  2. * suffered an acute, complete ACL rupture
  3. * have undergone ACL reconstructive surgery
  4. * willingness to participate in testing and follow-up as outlined in the protocol
  1. * have suffered a previous ACL injury;
  2. * have undergone previous major surgery to either knee;
  3. * have a history of recent significant knee injury (other than ACL) or lower-extremity fracture;
  4. * have a history of uncontrolled diabetes or hypertension;
  5. * be pregnant or plan to become pregnant;
  6. * have metal implants in the head;
  7. * have electronic devices in their ear or heart (e.g., cochlear implants or cardiac pacemakers);
  8. * have unexplained recurrent headaches;
  9. * have a recent history of seizures;
  10. * be taking drugs that reduce seizure threshold;
  11. * have a history of repeated fainting spells;

Contacts and Locations

Principal Investigator

Chandramouli Krishnan, PhD
PRINCIPAL_INVESTIGATOR
Assistant Professor

Study Locations (Sites)

University of Michigan
Ann Arbor, Michigan, 48108
United States

Collaborators and Investigators

Sponsor: University of Michigan

  • Chandramouli Krishnan, PhD, PRINCIPAL_INVESTIGATOR, Assistant Professor

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-09-21
Study Completion Date2025-11-24

Study Record Updates

Study Start Date2017-09-21
Study Completion Date2025-11-24

Terms related to this study

Keywords Provided by Researchers

  • Quadriceps activation deficits
  • ACL
  • Surgery
  • Quadrcieps weakness
  • Operant conditioning
  • Cortical excitability

Additional Relevant MeSH Terms

  • Anterior Cruciate Ligament Injury