Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

Description

The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.

Conditions

Anterior Cruciate Ligament Injury

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Study Overview

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Study Details

Study overview

The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.

Operant Conditioning of Motor Evoked Responses to Improve Quadriceps Function in Individuals With Anterior Cruciate Ligament Reconstruction

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

Condition
Anterior Cruciate Ligament Injury
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48108

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * aged 18-45 years
  • * suffered an acute, complete ACL rupture
  • * have undergone ACL reconstructive surgery
  • * willingness to participate in testing and follow-up as outlined in the protocol
  • * have suffered a previous ACL injury;
  • * have undergone previous major surgery to either knee;
  • * have a history of recent significant knee injury (other than ACL) or lower-extremity fracture;
  • * have a history of uncontrolled diabetes or hypertension;
  • * be pregnant or plan to become pregnant;
  • * have metal implants in the head;
  • * have electronic devices in their ear or heart (e.g., cochlear implants or cardiac pacemakers);
  • * have unexplained recurrent headaches;
  • * have a recent history of seizures;
  • * be taking drugs that reduce seizure threshold;
  • * have a history of repeated fainting spells;

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Michigan,

Chandramouli Krishnan, PhD, PRINCIPAL_INVESTIGATOR, Assistant Professor

Study Record Dates

2026-09