Ethanol Induces Skeletal Muscle Autophagy

Description

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.

Conditions

Alcoholic Liver Disease

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Study Overview

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Study Details

Study overview

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.

Mechanisms of Skeletal Muscle Proteolysis With Ethanol Consumption: an Integrated Molecular Metabolic Approach

Ethanol Induces Skeletal Muscle Autophagy

Condition
Alcoholic Liver Disease
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * clinical, biochemical, imaging criteria and liver biopsy where available
  • * Age 18 - 65 years old
  • * Serum liver transaminases (i.e. ALT and AST) 40 IU/L
  • * Normal liver ultrasound
  • * Age 18 - 65 years old
  • * Poorly controlled diabetes mellitus (HbA1C\>9.5 g/dl)
  • * Untreated Hyper- / hypo- thyroidism
  • * Patients on dialysis, renal disease with serum creatinine 1.5 mg/dL
  • * Active intravenous drug use
  • * History of bowel surgery or gastric bypass surgery
  • * Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids)
  • * Metastatic disease, Advanced cardiac or pulmonary disease
  • * Pregnancy
  • * Coagulopathy- INR \>1.4 and platelet count \<80,000/ml.

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The Cleveland Clinic,

Srinivasan Dasarathy, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2025-12-31