RECRUITING

Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper \[first toleration of solid food\] and lower \[first bowel movement\] gastrointestinal recovery) compared to placebo.

Official Title

A Randomized, Double-blind, Single-Center Trial of Alvimopan (Entereg) Versus Placebo in Patients Undergoing Radical Cystectomy and Urinary Diversion on an Enhanced Recovery After Surgery ERAS Protocol

Quick Facts

Study Start:2018-10-01

Study Completion:2024-06-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT03216525

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Patients undergoing radical cystectomy and urinary diversion via open or robotic approach. * Man or woman between the ages of 18 and 85. * American Society of Anesthesiologists (ASA) Physical Status Score of class 1-4 * Ileal conduit or ileal neobladder urinary diversion * Able to understand the study procedures, agreed to participate in the study program, and voluntarily provided informed consent	* Patients who met any of the following criteria were excluded from participating in the study: * Scheduled for a partial cystectomy * Previous total colectomy, gastrectomy, or gastric bypass, or functional colostomy or ileostomy * More than three doses of opioids (oral or parenteral) within 7 days before the day of surgery * Chemotherapy for bladder cancer within 1 month of scheduled surgery; prior neoadjuvant chemotherapy allowed. * Pregnant (identified by a positive serum pregnancy test administered after the initial screening process and before the commencement of study activities) or lactating, or not postmenopausal (no menses for at least 1 year) and of childbearing potential and not using an accepted method of birth control (i.e, surgical sterilization; intrauterine contraceptive device; oral contraceptive, diaphragm, or condom in combination with contraceptive cream, jelly, or foam; or abstinence) (Participants will be asked to use birth control for the entire study and for at least 2 weeks after the last dose of study drug.) * Participated in another investigational drug or medical device study within 30 days of surgery or planning to be enrolled in another investigational drug or medical device study or any study in which active patient participation was required outside normal hospital data collection during the course of this study * Clinically significant laboratory abnormalities at screening that would have resulted in the cancellation of surgery * Using illicit drugs or abusing alcohol * History of previous surgeries, illness, or behavior (eg, depression, psychosis) that in the opinion of the investigator might have confounded the study results or might have posed additional risk in administering the study procedures * Patients with severe dementia (as determined from medical records and history. Severe dementia will be defined as dementia that impacts daily functioning.) * Patients with severe hepatic impairment. * Patients with end-stage renal disease. * Patients with heart failure. . * Patients with complete gastrointestinal obstruction.

Inclusion Criteria

Exclusion Criteria

* Patients undergoing radical cystectomy and urinary diversion via open or robotic approach.
* Man or woman between the ages of 18 and 85.
* American Society of Anesthesiologists (ASA) Physical Status Score of class 1-4
* Ileal conduit or ileal neobladder urinary diversion
* Able to understand the study procedures, agreed to participate in the study program, and voluntarily provided informed consent

* Patients who met any of the following criteria were excluded from participating in the study:
* Scheduled for a partial cystectomy
* Previous total colectomy, gastrectomy, or gastric bypass, or functional colostomy or ileostomy
* More than three doses of opioids (oral or parenteral) within 7 days before the day of surgery
* Chemotherapy for bladder cancer within 1 month of scheduled surgery; prior neoadjuvant chemotherapy allowed.
* Pregnant (identified by a positive serum pregnancy test administered after the initial screening process and before the commencement of study activities) or lactating, or not postmenopausal (no menses for at least 1 year) and of childbearing potential and not using an accepted method of birth control (i.e, surgical sterilization; intrauterine contraceptive device; oral contraceptive, diaphragm, or condom in combination with contraceptive cream, jelly, or foam; or abstinence) (Participants will be asked to use birth control for the entire study and for at least 2 weeks after the last dose of study drug.)
* Participated in another investigational drug or medical device study within 30 days of surgery or planning to be enrolled in another investigational drug or medical device study or any study in which active patient participation was required outside normal hospital data collection during the course of this study
* Clinically significant laboratory abnormalities at screening that would have resulted in the cancellation of surgery
* Using illicit drugs or abusing alcohol
* History of previous surgeries, illness, or behavior (eg, depression, psychosis) that in the opinion of the investigator might have confounded the study results or might have posed additional risk in administering the study procedures
* Patients with severe dementia (as determined from medical records and history. Severe dementia will be defined as dementia that impacts daily functioning.)
* Patients with severe hepatic impairment.
* Patients with end-stage renal disease.
* Patients with heart failure. .
* Patients with complete gastrointestinal obstruction.

Contacts and Locations

Study Contact

Martin Barylak

CONTACT

6175258274

mbarylak@bwh.harvard.edu

Anjali Vasavada

CONTACT

6175258274

AVASAVADA@BWH.HARVARD.EDU

Principal Investigator

Mark A Preston, MD

PRINCIPAL_INVESTIGATOR

Brigham and Women's Hospital

Study Locations (Sites)

Brigham and Women's Hospital

Boston, Massachusetts, 02115

United States

Collaborators and Investigators

Sponsor: Brigham and Women's Hospital

Mark A Preston, MD, PRINCIPAL_INVESTIGATOR, Brigham and Women's Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-10-01

Study Completion Date2024-06-01

Study Record Updates

Study Start Date2018-10-01

Study Completion Date2024-06-01

Terms related to this study

Additional Relevant MeSH Terms

Bladder Cancer