Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Description

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

Conditions

Premature Ventricular Contraction (PVC)

Study Overview

Study Details

Study overview

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Condition
Premature Ventricular Contraction (PVC)
Intervention / Treatment

-

Contacts and Locations

New York

Weill Cornell Medicine, New York, New York, United States, 10065

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of premature ventricular contractions (PVCs)
  • * Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs
  • * Male or female between the ages of 18 and 70 years
  • * Capable of giving informed consent
  • * Any structural heart disease
  • * Coronary artery disease (≥ 70% stenosis)
  • * Current treatment with anti-arrhythmic drugs
  • * Pregnant
  • * Asthma (if administering adenosine)

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Weill Medical College of Cornell University,

James E Ip, M.D, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Study Record Dates

2025-12-31