Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

Description

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.

Conditions

Cirrhosis

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Study Overview

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Study Details

Study overview

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.

Multiple Tracer Using Single Muscle Biopsy Technique in Evaluating Protein Synthesis and Break Down in Muscles of Cirrhotic Patients

Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

Condition
Cirrhosis
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic Foundation, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria.
  • * Patients with Child Pugh score from A5- to B7
  • * Control group: Subject in control group should have serum ALT and AST within normal range.
  • * diabetes
  • * cancer
  • * kidney failure
  • * pregnancy
  • * recent surgery (bowel resection or Gastric bypass operation)
  • * Advanced cardiac or pulmonary disease
  • * patient with thyroid disease \& Coagulopathy ( INR \>1.4 and platelet count \<80,000/ml)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Srinivasan Dasarathy, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2025-09-30