Oxytocin and Fetal Heart Rate Changes

Description

The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.

Conditions

Fetal Bradycardia Complicating Labor and Delivery, Fetal Bradycardia During Labor, Fetal Heart Rate or Rhythm Abnormality Affecting Fetus

Study Overview

Study Details

Study overview

The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.

A Randomized Controlled Trial Evaluating the Effect of the Oxytocin Infusion Rate on Fetal Heart Rate Changes and Maternal-Fetal Outcomes During the Initiation of Combined Spinal-Epidural Labor Analgesia

Oxytocin and Fetal Heart Rate Changes

Condition
Fetal Bradycardia Complicating Labor and Delivery
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States, 52245

Milwaukee

Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 53226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy nulliparous or multiparous women at term (37 \> weeks' gestation)
  • * Singleton pregnancy
  • * Request for neuraxial analgesia
  • * Oxytocin used for induction of labor or augmentation of labor per institutional protocols
  • * Use of chronic analgesic medications
  • * Prior administration of systemic opioid labor analgesia
  • * Non-vertex presentation
  • * Contraindication to neuraxial analgesia
  • * Category 3 fetal heart rate tracing prior to the initiation of combined spinal epidural analgesia

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Unyime Ituk,

Unyime Ituk, STUDY_DIRECTOR, University of Iowa

Study Record Dates

2025-12-31