Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging

Eligibility Criteria

• * Subjects must be ≥30 and ≤75 years of age;
• * Subjects must provide informed consent prior to study procedures;
• * History of CAD, including:
• * Prior abnormal myocardial perfusion study
• * History of MI
• * History of angina
• * Coronary artery obstruction \>50% on CTA and/or angiography
• * Left ventricular ejection fraction \<50%
• * Any relative or absolute contraindication to adenosine stress, including:
• * 2nd or 3rd degree heart block
• * Bradycardia (HR\<50 bpm)
• * Recent acute coronary syndrome (ACS)
• * Unstable angina
• * Severe heart failure (left ventricular ejection fraction \<15%)
• * Ventricular arrhythmia
• * Severe asthma and/or chronic obstructive pulmonary disease (COPD)
• * Baseline hypotension defined as systolic blood pressure \< 90 mmHg
• * Caffeine intake within 24 hours prior to imaging
• * Current use of theophylline, dipyridamole, or carbamazepine
• * Allergy or intolerance to adenosine
• * Positive serum and/or urine pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
• * Subjects must be ≥30 and ≤75 years of age;
• * Subjects must provide informed consent prior to study procedures;
• * Abnormal myocardial perfusion study within the past 12 months
• * Revascularization (percutaneous coronary intervention and/or coronary artery bypass) following last myocardial perfusion study
• * Acute coronary syndrome within 30 days
• * Left ventricular ejection fraction \<50%
• * Any relative or absolute contraindication to adenosine stress, including:
• * 2nd or 3rd degree heart block
• * Bradycardia (HR\<50 bpm)
• * Recent acute coronary syndrome (ACS)
• * Unstable angina
• * Severe heart failure (left ventricular ejection fraction \<15%)
• * Ventricular arrhythmia
• * Severe asthma and/or chronic obstructive pulmonary disease (COPD)
• * Baseline hypotension defined as systolic blood pressure \< 90 mmHg
• * Caffeine intake within 24 hours prior to imaging
• * Current use of theophylline, dipyridamole, or carbamazepine
• * Allergy or intolerance to adenosine
• * Any clinically significant acute or unstable physical or psychological disease, judged by the investigators, to be incompatible with the study;
• * Radiation exposure exceeds current Radiology Department guidelines (i.e. 50 mSv in the prior 12 months);
• * Female participants only: Positive serum and/or urine pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
• * Inability to provide written informed consent;