Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection

Description

Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in in children, adolescents and young adults with refractory ADV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid organ transplant. Funding Source: FDA OOPD

Conditions

Adenovirus, Primary Immune Deficiency Disorder

Study Overview

Study Details

Study overview

Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in in children, adolescents and young adults with refractory ADV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid organ transplant. Funding Source: FDA OOPD

A Pilot Study in the Treatment of Refractory Adenovirus (ADV) Infection With Related Donor ADV Cytotoxic T-Lymphocytes (ADV-CTLs)in Children, Adolescents and Young Adult Recipients

Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection

Condition
Adenovirus
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Children's Hospital Los Angeles, Los Angeles, California, United States, 90027

San Francisco

University of California San Francisco, San Francisco, California, United States, 94158

Aurora

Children's Hospital of Colorado, Aurora, Colorado, United States, 80045

Aurora

University of Colorado Denver, Aurora, Colorado, United States, 80045

Indianapolis

Indiana University, Indianapolis, Indiana, United States, 46202

Baltimore

Johns Hopkins, Baltimore, Maryland, United States, 21287

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63130

Columbus

Nationwide Children's Hosptial, Columbus, Ohio, United States, 43205

Philadelphia

Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Milwaukee

Medical College of Wisconsin/Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States, 53226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    1 Month to 79 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    New York Medical College,

    Mitchell Cairo, MD, PRINCIPAL_INVESTIGATOR, New York Medical College

    Study Record Dates

    2026-12-31