Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Description

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.

Conditions

Autoimmune Diseases, Pregnancy Related, Systemic Lupus Erythematosus, Cutaneous Lupus, Rheumatoid Arthritis, Sjogren's Syndrome, Scleroderma

Study Overview

Study Details

Study overview

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Condition
Autoimmune Diseases
Intervention / Treatment

-

Contacts and Locations

Durham

Duke University, Durham, North Carolina, United States, 27705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Desire for pregnancy within 6 months or currently pregnant
  • * Women with systemic autoimmune disease, including:
  • * Lupus (systemic lupus erythematosus or cutaneous lupus)
  • * Antiphospholipid Syndrome or positive antiphospholipid antibodies
  • * Rheumatoid Arthritis
  • * Scleroderma (systemic sclerosis)
  • * Sjogren's Syndrome
  • * Inflammatory Arthritis (including Psoriatic Arthritis and Ankylosing Spondylitis)
  • * Undifferentiated Connective Tissue Disease (UCTD)
  • * Vasculitis
  • * Myositis (Polymyositis or Dermatomyositis)
  • * Positive Ro/SSA or La/SSB antibodies
  • * Unable to speak English
  • * Unable to provide informed consent
  • * Unable to travel to Duke University for follow-up visits

Ages Eligible for Study

to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Duke University,

Megan EB Clowse, MD, MPH, PRINCIPAL_INVESTIGATOR, Duke Health

Study Record Dates

2027-01-01