Ketorolac on Posterior Thoracolumbar Spinal Fusions

Description

To determine is low-dose ketorolac use in the early post-operative period (within 48 hours) provides adequate analgesia without long term adverse effect on spinal fusion rates when compared to post-operative analgesia without the use of NSAIDs.

Conditions

Thoracolumbar Spinal Fusions

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Study Overview

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Study Details

Study overview

To determine is low-dose ketorolac use in the early post-operative period (within 48 hours) provides adequate analgesia without long term adverse effect on spinal fusion rates when compared to post-operative analgesia without the use of NSAIDs.

The Effect of Ketorolac on Posterior Thoracolumbar Spinal Fusions: a Prospective Randomized Controlled Trial

Ketorolac on Posterior Thoracolumbar Spinal Fusions

Condition
Thoracolumbar Spinal Fusions
Intervention / Treatment

-

Contacts and Locations

Southfield

Providence-Providence Park, Southfield, Southfield, Michigan, United States, 48075

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Over 18 years of age
  • * Elective thoracolumbar posterior lumbar instrumented interbody fusion
  • * Minimally invasive spine surgery (MIS)
  • * 3 or fewer levels
  • * Bone Morphogenetic Protein (BMP) use in interbody fusion (1.05mg/level or less)
  • * Consent to study participation
  • * Active tobacco smoker or history of tobacco smoking in the past 6 weeks
  • * Previous history of surgery at operative level(s)
  • * History of chronic inflammatory/rheumatological condition
  • * History of systemic steroid use in the past 3 months
  • * Auto/Workers' compensation patients
  • * Traumatic pathology at the operative levels
  • * Infection at the operative levels
  • * Tumor at the operative levels
  • * Major psychiatric illness as diagnosed by psychiatrists and on major anti- psychotic/depressants
  • * Patients on chemotherapeutic agents in the last 6 months
  • * Patients who has a history of allergy to Ketorolac
  • * Patients with a history of chemical addiction requiring professional rehabilitation and/or assistance
  • * Patients with current creatinine \> 1.5mg/dl
  • * Patients with history of coagulopathy
  • * Patients with history of hepatic impairment
  • * Patients with uncontrolled cardiovascular disease

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ascension South East Michigan,

Doris Tong, MD, STUDY_DIRECTOR, Michigan Spine and Brain Surgeons

Study Record Dates

2025-12-31