Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

Description

The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.

Conditions

Giant Cell Tumor of Bone

Study Overview

Study Details

Study overview

The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: a Prospective Randomized Controlled Trial

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

Condition
Giant Cell Tumor of Bone
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California - Los Angeles, Los Angeles, California, United States, 90404

Indianapolis

Indiana University, Indianapolis, Indiana, United States, 46202

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Overland Park

University of Kansas, Overland Park, Kansas, United States, 66211

Baltimore

Johns Hopkins University Hospital, Baltimore, Maryland, United States, 21287

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Boston

Boston Children's Hospital, Boston, Massachusetts, United States, 02115

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Saint Louis

Saint Louis University, Saint Louis, Missouri, United States, 63110

Winston-Salem

Wake Forest University, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Primary benign GCT of bone
  • * Lesion located in an extremity
  • * Lesion amenable to reconstruction (intralesional curettage) defined as having at least one intact column of bone after removal
  • * No previous systemic bisphosphonate or denosumab therapy
  • * Recurrent GCT of bone
  • * Non-extremity location
  • * Lesion too extensive for intralesional treatment, either due to bone loss, joint invasion, or large soft tissue component
  • * Children and pregnancy
  • * Previous systemic bisphosphonate or denosumab therapy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

St. Louis University,

Study Record Dates

2027-01