Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham. Infants will be followed for three years to examine health outcomes including microbiome development, immune development, metabolic outcomes, and any adverse events.
Cesarean Delivery Affecting Newborn, Obesity, Childhood, Intestinal Microbiome, Microbiota, Host Microbial Interactions, Gastrointestinal Microbiome
Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham. Infants will be followed for three years to examine health outcomes including microbiome development, immune development, metabolic outcomes, and any adverse events.
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
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Inova Health System, Falls Church, Virginia, United States, 22042
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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0 Days to 50 Years
ALL
Yes
National Institute of Allergy and Infectious Diseases (NIAID),
Suchitra Hourigan, MD, Chief, Clinical Microbiome Unit, NIAID, Pediatric Gastroenterologist, PRINCIPAL_INVESTIGATOR, National Institute of Allergy and Infectious Diseases (NIAID), Inova Children's Hospital
Noel Mueller, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University
Maria Gloria Dominguez Bello, PhD, PRINCIPAL_INVESTIGATOR, Rutgers University
Lawrence Appel, MD, MPH, PRINCIPAL_INVESTIGATOR, Johns Hopkins University
2029-04