Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

Description

Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.

Conditions

Pre-Eclampsia, Gestational Hypertension, Superimposed Pre-Eclampsia, Hypertension, Pregnancy-Induced, Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia

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Study Overview

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Study Details

Study overview

Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide: a Randomized Clinical Trial

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

Condition
Pre-Eclampsia
Intervention / Treatment

-

Contacts and Locations

Austin

St. David's North Austin Medical Center, Austin, Texas, United States, 78758

Galveston

University of Texas Medical Branch, Galveston, Texas, United States, 77555

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Maternal age ≥ 18 years and \<50 years.
  • * Diagnosis of gestational hypertension\* or preeclampsia\^ at any time during pregnancy, labor or postpartum.
  • * defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm Hg or greater, or both) or \^ defines as new-onset hypertension plus new-onset proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as hypertension in association with thrombocytopenia (platelet count less than 100,000/microliter), impaired liver function (elevated blood levels of liver transaminases to twice the normal concentration), the new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.)
  • * Subject requiring antihypertensive therapy at time of screening.
  • * Planned discharge with oral anti-hypertensive medication.
  • * Contraindication to hydrochlorothiazide (advanced renal failure or anuria, hypersensitivity to sulfonamides).
  • * Subject not able to follow up postpartum.
  • * Lactose intolerance.
  • * Pre-gestational diabetes.

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

The University of Texas Medical Branch, Galveston,

Benjamin Bush, M.D., PRINCIPAL_INVESTIGATOR, UTMB

Study Record Dates

2024-08-30