RECRUITING

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

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Conditions

Pre-EclampsiaGestational HypertensionSuperimposed Pre-EclampsiaHypertension, Pregnancy-InducedPostpartum Pregnancy-Induced HypertensionPostpartum Preeclampsiareadmissiontriage visit for pregnancy related hypertensionhydrochlorothiazide

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.

Official Title

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide: a Randomized Clinical Trial

Quick Facts

Study Start:2017-11-21
Study Completion:2024-08-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03298802

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Maternal age ≥ 18 years and \<50 years.
  2. * Diagnosis of gestational hypertension\* or preeclampsia\^ at any time during pregnancy, labor or postpartum.
  3. * defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm Hg or greater, or both) or \^ defines as new-onset hypertension plus new-onset proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as hypertension in association with thrombocytopenia (platelet count less than 100,000/microliter), impaired liver function (elevated blood levels of liver transaminases to twice the normal concentration), the new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.)
  1. * Subject requiring antihypertensive therapy at time of screening.
  2. * Planned discharge with oral anti-hypertensive medication.
  3. * Contraindication to hydrochlorothiazide (advanced renal failure or anuria, hypersensitivity to sulfonamides).
  4. * Subject not able to follow up postpartum.
  5. * Lactose intolerance.
  6. * Pre-gestational diabetes.

Contacts and Locations

Study Contact

Megan C Shepherd, M.D.
CONTACT
409-772-0312
mcshephe@UTMB.EDU
Ashley Salazar, RN
CONTACT
409-772-0312
assalaza@utmb.edu

Principal Investigator

Benjamin Bush, M.D.
PRINCIPAL_INVESTIGATOR
UTMB

Study Locations (Sites)

St. David's North Austin Medical Center
Austin, Texas, 78758
United States
University of Texas Medical Branch
Galveston, Texas, 77555
United States

Collaborators and Investigators

Sponsor: The University of Texas Medical Branch, Galveston

  • Benjamin Bush, M.D., PRINCIPAL_INVESTIGATOR, UTMB

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-11-21
Study Completion Date2024-08-30

Study Record Updates

Study Start Date2017-11-21
Study Completion Date2024-08-30

Terms related to this study

Keywords Provided by Researchers

  • readmission
  • triage visit for pregnancy related hypertension
  • hydrochlorothiazide

Additional Relevant MeSH Terms

  • Pre-Eclampsia
  • Gestational Hypertension
  • Superimposed Pre-Eclampsia
  • Hypertension, Pregnancy-Induced
  • Postpartum Pregnancy-Induced Hypertension
  • Postpartum Preeclampsia