Improving Measurement and Treatment of Post-stroke Neglect

Description

This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.

Conditions

Stroke

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Study Overview

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Study Details

Study overview

This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.

Improving Measurement and Treatment of Post-stroke Neglect

Improving Measurement and Treatment of Post-stroke Neglect

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania, United States, 15240

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ischemic or hemorrhagic stroke 3 months post stroke.
  • * Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60
  • * Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS)
  • * Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score \<18)
  • * History of cortical hemorrhagic stroke
  • * Presence of any MRI, TMS, tDCS risk factors including:
  • * history of seizures
  • * history of brain tumor
  • * hardware in skull or spine (e.g. coils, clips)
  • * implantable medical device (e.g. pacemaker)
  • * metal in body (not compatible with MRI)
  • * pregnancy
  • * Severe spasticity (Modified Ashworth Scale score 3)
  • * Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2)
  • * Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, MOU approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Emily S. Grattan, PhD MS BS, PRINCIPAL_INVESTIGATOR, VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Study Record Dates

2025-09-30