RECRUITING

Improving Measurement and Treatment of Post-stroke Neglect

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.

Official Title

Improving Measurement and Treatment of Post-stroke Neglect

Quick Facts

Study Start:2018-07-02
Study Completion:2025-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03317860

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ischemic or hemorrhagic stroke 3 months post stroke.
  2. * Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60
  3. * Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS)
  4. * Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score \<18)
  1. * History of cortical hemorrhagic stroke
  2. * Presence of any MRI, TMS, tDCS risk factors including:
  3. * history of seizures
  4. * history of brain tumor
  5. * hardware in skull or spine (e.g. coils, clips)
  6. * implantable medical device (e.g. pacemaker)
  7. * metal in body (not compatible with MRI)
  8. * pregnancy
  9. * Severe spasticity (Modified Ashworth Scale score 3)
  10. * Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2)
  11. * Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, MOU approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study

Contacts and Locations

Study Contact

Emily S Grattan, PhD MS BS
CONTACT
(412) 559-4920
ESG39@pitt.edu
George F Wittenberg, MD PhD
CONTACT
(412) 360-6185
George.Wittenberg@va.gov

Principal Investigator

Emily S. Grattan, PhD MS BS
PRINCIPAL_INVESTIGATOR
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Study Locations (Sites)

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
Pittsburgh, Pennsylvania, 15240
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Emily S. Grattan, PhD MS BS, PRINCIPAL_INVESTIGATOR, VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-07-02
Study Completion Date2025-09-30

Study Record Updates

Study Start Date2018-07-02
Study Completion Date2025-09-30

Terms related to this study

Keywords Provided by Researchers

  • perceptual disorders
  • cerebrovascular disorders
  • neurobehavioral manifestations
  • neurologic manifestations
  • neglect
  • non-invasive brain stimulation
  • rehabilitation
  • tDCS
  • paresis

Additional Relevant MeSH Terms

  • Stroke