Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Description

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.

Conditions

Chronic Obstructive Pulmonary Disease

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Study Overview

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Study Details

Study overview

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Condition
Chronic Obstructive Pulmonary Disease
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia Health System, Charlottesville, Virginia, United States, 22908

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects must have a diagnosis of COPD
  • * at their clinical baseline on the day of imaging
  • * must be clinically stable in order to participate in the study.
  • * COPD subjects will be categorized according to the GOLD
  • * Current/Former SmokerSubjects
  • * must have a smoking history ≥ 10 pack years
  • * Dx of asthma
  • * Continuous oxygen use at home
  • * Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging
  • * FEV1 percent predicted less than 25%
  • * Pregnancy or lactation
  • * Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning
  • * Subjects with any implanted device that cannot be verified as MRI compliant will be excluded
  • * Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches
  • * History of congenital cardiac disease, chronic renal failure, or cirrhosis
  • * Inability to understand simple instructions or to hold still for approximately 10 seconds
  • * History of respiratory infection within 2 weeks prior to the MR scan
  • * History of MI, stroke and/or poorly controlled hypertension.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Virginia,

Yun M Shim, MD, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

2020-12-31