RECRUITING

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

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Conditions

Chronic Obstructive Pulmonary Disease

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.

Official Title

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Quick Facts

Study Start:2018-09-01
Study Completion:2020-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03331302

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Subjects must have a diagnosis of COPD
  2. * at their clinical baseline on the day of imaging
  3. * must be clinically stable in order to participate in the study.
  4. * COPD subjects will be categorized according to the GOLD
  5. * Current/Former SmokerSubjects
  6. * must have a smoking history ≥ 10 pack years
  1. * Dx of asthma
  2. * Continuous oxygen use at home
  3. * Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging
  4. * FEV1 percent predicted less than 25%
  5. * Pregnancy or lactation
  6. * Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning
  7. * Subjects with any implanted device that cannot be verified as MRI compliant will be excluded
  8. * Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches
  9. * History of congenital cardiac disease, chronic renal failure, or cirrhosis
  10. * Inability to understand simple instructions or to hold still for approximately 10 seconds
  11. * History of respiratory infection within 2 weeks prior to the MR scan
  12. * History of MI, stroke and/or poorly controlled hypertension.

Contacts and Locations

Study Contact

Sarah Struchen, RN
CONTACT
4342436074
SS8YM@hscmail.mcc.virginia.edu
Roselove Nunoo-Asare, RT
CONTACT
4342437363
RNN3B@hscmail.mcc.virginia.edu

Principal Investigator

Yun M Shim, MD
PRINCIPAL_INVESTIGATOR
University of Virginia

Study Locations (Sites)

University of Virginia Health System
Charlottesville, Virginia, 22908
United States

Collaborators and Investigators

Sponsor: University of Virginia

  • Yun M Shim, MD, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-09-01
Study Completion Date2020-12-31

Study Record Updates

Study Start Date2018-09-01
Study Completion Date2020-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Chronic Obstructive Pulmonary Disease