Assessing Neurocognition After Cerebrovascular Intervention

Description

Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.

Conditions

Carotid Artery Diseases, Neurocognitive Dysfunction

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Study Overview

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Study Details

Study overview

Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.

Assessing Neurocognition After Cerebrovascular Intervention

Assessing Neurocognition After Cerebrovascular Intervention

Condition
Carotid Artery Diseases
Intervention / Treatment

-

Contacts and Locations

San Diego

UCSD Medical Center, San Diego, California, United States, 92103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * patients \>18 years of age
  • * ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis.
  • 1. patients \<18 years of age
  • 2. patients with without compatibility for MRI
  • 3. patients requiring carotid stenting for reasons not related to long-standing stenosis
  • 4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure.
  • 5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Alexander A Khalessi, MD, PRINCIPAL_INVESTIGATOR, UC San Diego

David R Santiago-Dieppa, MD, STUDY_DIRECTOR, UC San Diego

Study Record Dates

2025-12