RECRUITING

Assessing Neurocognition After Cerebrovascular Intervention

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.

Official Title

Assessing Neurocognition After Cerebrovascular Intervention

Quick Facts

Study Start:2021-07-15
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03344276

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * patients \>18 years of age
  2. * ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis.
  1. 1. patients \<18 years of age
  2. 2. patients with without compatibility for MRI
  3. 3. patients requiring carotid stenting for reasons not related to long-standing stenosis
  4. 4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure.
  5. 5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.

Contacts and Locations

Study Contact

Alexander Khalessi, MD
CONTACT
(619) 543-5540
akhalessi@ucsd.edu
ARVIN WALI, BA, MAS
CONTACT
7149282722
AWALI@UCSD.EDU

Principal Investigator

Alexander A Khalessi, MD
PRINCIPAL_INVESTIGATOR
UC San Diego
David R Santiago-Dieppa, MD
STUDY_DIRECTOR
UC San Diego

Study Locations (Sites)

UCSD Medical Center
San Diego, California, 92103
United States

Collaborators and Investigators

Sponsor: University of California, San Diego

  • Alexander A Khalessi, MD, PRINCIPAL_INVESTIGATOR, UC San Diego
  • David R Santiago-Dieppa, MD, STUDY_DIRECTOR, UC San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-15
Study Completion Date2025-12

Study Record Updates

Study Start Date2021-07-15
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • carotid stenosis
  • neurocognition
  • carotid stenting
  • circle of willis

Additional Relevant MeSH Terms

  • Carotid Artery Diseases
  • Neurocognitive Dysfunction