Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

Description

This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.

Conditions

Diabetes Mellitus, Type 2, Hypertension, Vitamin D Deficiency

Study Overview

Study Details

Study overview

This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics

Condition
Diabetes Mellitus, Type 2
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Barnes-Jewish & Washington University Diabetes Center, Saint Louis, Missouri, United States, 63110

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Type 2 diabetes (T2DM)
  • * Age: 25-80 years old
  • * Vitamin 25(OH)D3 levels \<20 or \>30 ng/ml.
  • * HbA1c: 5.5%-9.5%
  • * Blood Pressure: \<160/100 mm Hg on BP lowering medications and
  • * Blood Pressure: \>120/80 to 160/100 mmHg without BP lowering medications
  • * Recent weight loss of more than 5% within 3 months prior to screening
  • * Current Pregnancy
  • * Hypercalcemia
  • * Previous heart attack and stroke
  • * Heart failure
  • * Atrial fibrillation
  • * Heavy alcohol consumption
  • * Extreme diets (Atkins, South Beach)
  • * Chronic renal failure: stage 4 or worse
  • * \>2 + proteinuria on urine sample
  • * Chronic diseases known to affect immunity

Ages Eligible for Study

25 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

Carlos Bernal-Mizrachi, MD, STUDY_DIRECTOR, Washington University School of Medicine

Study Record Dates

2024-12-31