In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

Description

This pilot study will first establish the feasibility of an in vivo methodology of assessing the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from healthy subjects while comparing it to an ex vivo approach

Conditions

Healthy

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Study Overview

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Study Details

Study overview

This pilot study will first establish the feasibility of an in vivo methodology of assessing the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from healthy subjects while comparing it to an ex vivo approach

In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells in Healthy Subjects Using Stable Isotope Resolved Metabolomics: A Pilot Study

In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18-60
  • * Able to provide written consent
  • * Renal Failure
  • * Pregnancy
  • * Active steroid use
  • * Active liver Disease
  • * Anemia (Hemoglobin \< 12.5 g/dL in men and \< 11.5 g/dL in women)
  • * H/O alcohol use (average \> 2 drinks per day)
  • * BMI \> 30

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Wilson Gonsalves, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2026-01