Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

Description

The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.

Conditions

Pediatric Anesthesia

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Study Overview

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Study Details

Study overview

The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.

Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

Condition
Pediatric Anesthesia
Intervention / Treatment

-

Contacts and Locations

Houston

Texas Children's Hospital, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation
  • 2. History of difficult intubation or ventilation
  • 3. Airway malformation
  • 4. Congenital heart disease
  • 5. Cardiac arrhythmias
  • 6. Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder
  • 7. History of or family history of malignant hyperthermia
  • 8. Electrolyte disorders
  • 9. Gastrointestinal disease
  • 10. Hepatic dysfunction
  • 11. Renal dysfunction
  • 12. Metabolic disease, such as diabetes
  • 13. Obesity, defined as a body mass index greater than the 95% percentile for age
  • 14. Preterm infant (less than 37 weeks gestational age) 15. Use of any medications (anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines drugs that induce hepatic enzymes) that may affect MAC.

Ages Eligible for Study

1 Month to 36 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Baylor College of Medicine,

Rahul Baijal, MD, PRINCIPAL_INVESTIGATOR, Baylor College of Medicine

Study Record Dates

2025-12-31