Peripheral Nerve Blocks for Above-the-knee Amputations

Description

Surgery performed with nerve blocks and sedation may be safer and provide better pain control compared to general anesthesia and opioid therapy in high-risk patient populations such as elderly and troubled with peripheral vascular disease, diabetes, hypertension, coronary artery disease, and chronic obstructive pulmonary disease (COPD).

Conditions

Peripheral Vascular Diseases, Hyperglycaemia (Diabetic), Hypertension, Coronary Artery Disease, Pulmonary Disease, Chronic Obstructive

Study Overview

Study Details

Study overview

Surgery performed with nerve blocks and sedation may be safer and provide better pain control compared to general anesthesia and opioid therapy in high-risk patient populations such as elderly and troubled with peripheral vascular disease, diabetes, hypertension, coronary artery disease, and chronic obstructive pulmonary disease (COPD).

Peripheral Nerve Blocks for Upper Leg Amputations

Peripheral Nerve Blocks for Above-the-knee Amputations

Condition
Peripheral Vascular Diseases
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients undergoing above-the-knee amputation or knee disarticulation
  • * Ability to understand and provide informed consent
  • * Patient refusal or inability to provide informed consent
  • * True allergy, not sensitivity, to any of the following substances:
  • * - Local anesthetics
  • * - Propofol or other sedative agents
  • * - General anesthetic agents
  • * Pregnancy
  • * Severe hepatic impairment
  • * Evidence of infection at or near the proposed needle insertion site
  • * Any sensorimotor deficit, whether acute or chronic, as determined by the PI
  • * Chronic use of opioid medication
  • * BMI ≥ 35

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

José R Soberón, MD, PRINCIPAL_INVESTIGATOR, Malcom Randall VA Medical Center

Study Record Dates

2025-08-04