Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients

Description

Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients

Conditions

HIV Infections

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Study Overview

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Study Details

Study overview

Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients

Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients

Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients

Condition
HIV Infections
Intervention / Treatment

-

Contacts and Locations

Chicago

Northwestern University, Chicago, Illinois, United States, 60611

Baltimore

Johns Hopkins University, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Able to understand and provide consent
  • * Age 21 years or older
  • * Meets standard clinical criteria for living donation per Johns Hopkins University (JHU) Comprehensive Transplant Center Policy
  • * Documented HIV infection (by any licensed Enzyme-linked Immunosorbent Assay (ELISA) and confirmation by Western Blot, positive HIV Ab Immunofluorescent Assay (IFA), or documented history of detectable HIV-1 RNA)
  • * CD4+ T-cell count ≥ 500/µL for 6 months prior to donation
  • * HIV-1 RNA below 50 copies RNA/mL (viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \>200 copies/mL)
  • * Two high risk alleles of APOL1 (G1 or G2 variants)
  • * Hypertension
  • * Diabetes
  • * Chronic active hepatitis C (detectable HCV RNA in plasma)
  • * Evidence of invasive opportunistic complications from HIV infection
  • * Mentally incompetent and/or inability to provide informed consent
  • * Other medical conditions, as determined by the provider, that would preclude donation

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Christine Durand, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2030-08-01