Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty

Description

This is an open label study of Riociguat in patients with continued exercise intolerance at least 6 months following pulmonary endarterectomy (PEA).

Conditions

Chronic Thromboembolic Disease (CTED), Exercise Intolerance Post PEA Surgery

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Study Overview

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Study Details

Study overview

This is an open label study of Riociguat in patients with continued exercise intolerance at least 6 months following pulmonary endarterectomy (PEA).

Treatment of Exercise-Induced Pulmonary Vascular Dysfunction in Symptomatic Patients After Pulmonary Thromboendarterectomy

Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty

Condition
Chronic Thromboembolic Disease (CTED)
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients who underwent PTE or BPA for Chronic thromboembolic pulmonary hypertension (CTEPH) at least six months prior to screening and report ongoing subjective exercise limitation,
  • * able to give consent
  • * able to perform a exercise protocol
  • * Patients with known Residual Pulmonary Hypertension (RPH) by RHC following PTE for CTEPH
  • * ongoing PAH-specific vasodilator therapy
  • * known contraindication to riociguat
  • * a physical limitation to completing an exercise protocol

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Todd Bull, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Peter Sottile, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

William Cornwell, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Study Record Dates

2024-12