COMPLETED

Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty

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Conditions

Chronic Thromboembolic Disease (CTED)Exercise Intolerance Post PEA SurgeryChronic Thromboembolic DiseaseCTEDTreatment Post PEA surgery

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is an open label study of Riociguat in patients with continued exercise intolerance at least 6 months following pulmonary endarterectomy (PEA).

Official Title

Treatment of Exercise-Induced Pulmonary Vascular Dysfunction in Symptomatic Patients After Pulmonary Thromboendarterectomy

Quick Facts

Study Start:2018-06-13
Study Completion:2026-01-26
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT03409588

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult patients who underwent PTE or BPA for Chronic thromboembolic pulmonary hypertension (CTEPH) at least six months prior to screening and report ongoing subjective exercise limitation,
  2. * able to give consent
  3. * able to perform a exercise protocol
  1. * Patients with known Residual Pulmonary Hypertension (RPH) by RHC following PTE for CTEPH
  2. * ongoing PAH-specific vasodilator therapy
  3. * known contraindication to riociguat
  4. * a physical limitation to completing an exercise protocol

Contacts and Locations

Principal Investigator

Todd Bull, MD
PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Peter Sottile, MD
PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
William Cornwell, MD
PRINCIPAL_INVESTIGATOR
University of Colorado, Denver

Study Locations (Sites)

University of Colorado, Anschutz Medical Campus
Aurora, Colorado, 80045
United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

  • Todd Bull, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver
  • Peter Sottile, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver
  • William Cornwell, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-06-13
Study Completion Date2026-01-26

Study Record Updates

Study Start Date2018-06-13
Study Completion Date2026-01-26

Terms related to this study

Keywords Provided by Researchers

  • Chronic Thromboembolic Disease
  • CTED
  • Treatment Post PEA surgery

Additional Relevant MeSH Terms

  • Chronic Thromboembolic Disease (CTED)
  • Exercise Intolerance Post PEA Surgery