Phenotyping Asthma for Bronchial Thermoplasty

Description

This study will evaluate a new imaging technology, called optical coherence tomography (OCT) to examine the asthmatic airways before and after bronchial thermoplasty, which is a new treatment option for severe asthmatic patients. The aim of this study is to learn more about how airways respond to this new treatment. In the future the investigators hope OCT will aid clinicians in the initial assessment, management and long-term follow up of patients receiving bronchial thermoplasty.

Conditions

Severe Asthma

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Study Overview

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Study Details

Study overview

This study will evaluate a new imaging technology, called optical coherence tomography (OCT) to examine the asthmatic airways before and after bronchial thermoplasty, which is a new treatment option for severe asthmatic patients. The aim of this study is to learn more about how airways respond to this new treatment. In the future the investigators hope OCT will aid clinicians in the initial assessment, management and long-term follow up of patients receiving bronchial thermoplasty.

Phenotyping Asthma for Bronchial Thermoplasty: Airway Smooth Muscle Structure and Function

Phenotyping Asthma for Bronchial Thermoplasty

Condition
Severe Asthma
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patient undergoing elective bronchial thermoplasty
  • 2. Patient is between the ages of 18 and 60
  • 3. Patient is able to give informed consent
  • 4. Negative pregnancy test for all female of childbearing potential who are sexually active and not using contraception, are seeking to become pregnant, or who are nursing.
  • 5. Nonsmoking (\<5 pack year tobacco exposure)
  • 6. No history of co-existing lung disease
  • 7. Meet American Thoracic Society criteria for diagnosis of asthma with either/or
  • 1. Bronchodilator response to albuterol (≥12% change in FEV1)
  • 2. Positive methacholine bronchoprovocation (PC20 \< 25 mg/ml)
  • 1. Patients who are pregnant.
  • 2. Patient does not meet the requirements to undergo clinical bronchial thermoplasty, as determined by the treating physician

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Melissa J Suter, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2024-12