RECRUITING

Phenotyping Asthma for Bronchial Thermoplasty

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will evaluate a new imaging technology, called optical coherence tomography (OCT) to examine the asthmatic airways before and after bronchial thermoplasty, which is a new treatment option for severe asthmatic patients. The aim of this study is to learn more about how airways respond to this new treatment. In the future the investigators hope OCT will aid clinicians in the initial assessment, management and long-term follow up of patients receiving bronchial thermoplasty.

Official Title

Phenotyping Asthma for Bronchial Thermoplasty: Airway Smooth Muscle Structure and Function

Quick Facts

Study Start:2021-05-10
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03435237

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Patient undergoing elective bronchial thermoplasty
  2. 2. Patient is between the ages of 18 and 60
  3. 3. Patient is able to give informed consent
  4. 4. Negative pregnancy test for all female of childbearing potential who are sexually active and not using contraception, are seeking to become pregnant, or who are nursing.
  5. 5. Nonsmoking (\<5 pack year tobacco exposure)
  6. 6. No history of co-existing lung disease
  7. 7. Meet American Thoracic Society criteria for diagnosis of asthma with either/or
  8. 1. Bronchodilator response to albuterol (≥12% change in FEV1)
  9. 2. Positive methacholine bronchoprovocation (PC20 \< 25 mg/ml)
  1. 1. Patients who are pregnant.
  2. 2. Patient does not meet the requirements to undergo clinical bronchial thermoplasty, as determined by the treating physician

Contacts and Locations

Study Contact

Melissa J Suter, PhD
CONTACT
617-724-7691
msuter@mgh.harvard.edu

Principal Investigator

Melissa J Suter, PhD
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Melissa J Suter, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-05-10
Study Completion Date2024-12

Study Record Updates

Study Start Date2021-05-10
Study Completion Date2024-12

Terms related to this study

Keywords Provided by Researchers

  • Optical Coherence Tomography
  • Bronchial Thermoplasty

Additional Relevant MeSH Terms

  • Severe Asthma