Alternation in the Human Microbiome With Commonly Used Topical Medications

Description

The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: 1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.

Conditions

Healthy

Study Overview

Study Details

Study overview

The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: 1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.

Alterations in the Human Microbiome With Commonly Used Topical Medications

Alternation in the Human Microbiome With Commonly Used Topical Medications

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

Sacramento

University of California, Davis, Department of Dermatology, Sacramento, California, United States, 95816

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions.
  • * Patients with a history of skin cancer, multiple nevi, or other isolated lesions will not be excluded.
  • * Individuals who have used topical, intravenous, intramuscular, or oral antibiotics within the last 6 months
  • * Individuals with known allergies to any of the study medications.
  • * Individuals younger than 18 years of age.
  • * Adults unable to consent
  • * Non-English speaking individuals. Given the complexity in the instructions that subjects will need to follow for proper sample collection, we will not seek to recruit non-English speaking individuals for this pilot study.
  • * Prisoners

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Emanual Maverakis, MD, PRINCIPAL_INVESTIGATOR, UC Davis

Study Record Dates

2026-09-28