TERMINATED

Grasping Function After Spinal Cord Injury

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Conditions

Spinal Cord Injuryneural controlmotor functionhand movement

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overall goals of this proposal are to examine the contribution of physiological pathways to the control of grasping behaviors after cervical SCI, and to maximize the recovery of grasping by using tailored non-invasive brain stimulation and acoustic startle protocols with motor training. The investigators propose to study two basic grasping behaviors, which are largely used in most daily-life activities: a precision grip and a power grip.

Official Title

Grasping Function After Spinal Cord Injury

Quick Facts

Study Start:2020-03-17
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT03447509

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male and females between ages 18-85 years
  2. * Right handed
  3. * Able to complete precision grips with both hands
  4. * Able to complete full wrist flexion-extension bilaterally
  5. * Male and females between ages 18-85 years
  6. * Chronic SCI (\> 1 year post injury)
  7. * Spinal Cord injury at C8 or above
  8. * Intact or impaired but not absent innervations in dermatomes C6. C7 and C8 during light touch and pin prick stimulus using the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) sensory scores
  9. * The ability to produce a visible precision grip force with one hand
  10. * Able to perform some small wrist flexion and extension
  11. * ASIA A,B,C, or D
  1. * Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
  2. * Any debilitating disease prior to the SCI that caused exercise intolerance
  3. * Premorbid, ongoing major depression or psychosis, altered cognitive status
  4. * History of head injury or stroke
  5. * Pacemaker
  6. * Metal plate in skull
  7. * History of seizures
  8. * Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold
  9. * Pregnant females
  10. * Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk

Contacts and Locations

Principal Investigator

Monica A Perez, PhD
PRINCIPAL_INVESTIGATOR
Edward Hines Jr. VA Hospital, Hines, IL

Study Locations (Sites)

Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, 60141-3030
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Monica A Perez, PhD, PRINCIPAL_INVESTIGATOR, Edward Hines Jr. VA Hospital, Hines, IL

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-03-17
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2020-03-17
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • Spinal cord injury
  • neural control
  • motor function
  • hand movement

Additional Relevant MeSH Terms

  • Spinal Cord Injury