The study schema is shown in Figure 4. (A) All patients referred to one of the participating academic centers for EUS evaluation of the PCL will be enrolled in the protocol if they satisfy inclusion criteria. Patient consent will be obtained during the clinic visit or prior to their EUS. EUS-guided nCLE imaging is first performed (B) followed by EUS-guided FNA and aspiration of cyst fluid. The cyst fluid is analyzed for CEA and cytology. As per institutional standard of care, the cyst fluid is also sent for molecular analysis. The results of the cyst fluid molecular analysis (B) will be utilized for the most likely diagnosis. Based on institutional multidisciplinary tumor board meetings, surgery is performed as indicated (C). Surgical histopathology serves as "gold standard" for diagnosis. It is anticipated that the majority of patients will undergo surgical resection after their EUS.
Pancreatic Cyst
The study schema is shown in Figure 4. (A) All patients referred to one of the participating academic centers for EUS evaluation of the PCL will be enrolled in the protocol if they satisfy inclusion criteria. Patient consent will be obtained during the clinic visit or prior to their EUS. EUS-guided nCLE imaging is first performed (B) followed by EUS-guided FNA and aspiration of cyst fluid. The cyst fluid is analyzed for CEA and cytology. As per institutional standard of care, the cyst fluid is also sent for molecular analysis. The results of the cyst fluid molecular analysis (B) will be utilized for the most likely diagnosis. Based on institutional multidisciplinary tumor board meetings, surgery is performed as indicated (C). Surgical histopathology serves as "gold standard" for diagnosis. It is anticipated that the majority of patients will undergo surgical resection after their EUS.
Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions
-
Mayo Clinic Scottsdale Campus, Scottsdale, Arizona, United States, 85259
Stanford Hospital, Stanford, California, United States, 94305
Yale School of Medicine, New Haven, Connecticut, United States, 06510
Parkview Hospital Randallia, Fort Wayne, Indiana, United States, 46805
The Johns Hopkins Hospital, Baltimore, Maryland, United States, 21287
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215
NYU Langone Health, Garden City, New York, United States, 11530
Icahn School of Medicine at Mount Sinai, New York, New York, United States, 10029
The Ohio State University Wexner Medical Center, Columbus, Ohio, United States, 43210
Baylor College of Medicine, Houston, Texas, United States, 77030
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
Ohio State University Comprehensive Cancer Center,
Somashekar Krishna, MD, MPH, PRINCIPAL_INVESTIGATOR, The Ohio State University Wexner Medical Center
2025-12-31